Cytiva GE Hollow Fiber Filter Tangential Flow Cartridge 0.1um 1200cm2

Cytiva 56-4102-47 CFP-1-E-5A Hollow Fiber Cartridge – 0.1 µm, 1.0 mm Lumen

The Cytiva 56-4102-47 (model CFP-1-E-5A) is an advanced Tangential Flow Filtration (TFF) hollow fiber cartridge designed for critical microfiltration operations in biopharmaceutical manufacturing and pilot-scale process development. Unlike standard dead-end filters, this cartridge utilizes a cross-flow fluid path that continuously sweeps across the membrane surface. This dynamic action prevents the rapid buildup of a polarization layer, significantly reducing fouling and extending the operational life of the filter during high-volume processing. Equipped with a precise 0.1 µm pore size and a 1.0 mm lumen, the CFP-1-E-5A provides a gentle, low-shear environment perfect for processing moderately viscous, high-solids cell suspensions. With 0.12 m² (1,200 cm²) of active surface area housed within a compact 30 cm path length, this module delivers highly accurate performance data while minimizing the higher inlet pressures associated with longer cartridges.

Technical Performance and Design

• Tangential Flow Dynamics: The continuous sweep of the feed stream across the hollow fibers actively mitigates membrane fouling, allowing for much higher volumetric throughput and longer continuous run times than standard normal-flow filters.

• 0.1 µm Microfiltration Membrane: Provides a precise and absolute barrier for large particulates and whole cells, making it the industry standard for upstream clarification, yeast removal, or large-virus concentration.

• 1.0 mm Lumen Diameter: The 1.0 mm internal diameter of the hollow fibers ensures that highly concentrated biomass, cell lysates, or viscous broths can be circulated without generating excessive shear stress or prematurely plugging the fluid path.

• Pilot-Scale Optimization: The 30 cm path length is strategically designed to manage frictional pressure drops effectively, making it ideal for arraying multiple cartridges in series during pilot-scale linear scale-up.

Product Specifications

• Catalog Number: 56-4102-47 (Model: CFP-1-E-5A)

• Filtration Type: Tangential Flow Filtration (TFF) / Microfiltration

• Pore Size: 0.1 µm

• Fiber Inner Diameter (Lumen): 1.0 mm

• Path Length: 30 cm

• Membrane Area: 0.12 m² (1,200 cm²)

Key Benefits & Applications

• Gentle Cell Harvesting: The open lumen and low-shear fluid dynamics make it the gold standard for concentrating fragile mammalian cells (like CHO or HEK293) while maintaining extremely high cell viability.

• Lysate Clarification: Acts as a highly efficient primary clarification step to remove bulk cellular debris before sending the targeted supernatant to sensitive downstream chromatography columns.

• Reduced Transmembrane Pressure: The shorter 30 cm path length ensures an optimal pressure differential, allowing feed pumps to operate efficiently without over-pressurizing the retentate lines.

• Reusable & Cleanable: Designed to withstand rigorous Clean-In-Place (CIP) protocols—including prolonged exposure to sodium hydroxide (NaOH)—allowing the cartridge to be safely regenerated and repeatedly deployed.

All product names, logos, and brands are property of their respective owners.