Millipore Filter Microplate MultiScreen HTS DV 0.65 um Hydrophilic Duropore 10 Sets

Millipore MultiScreenHTS Durapore Filter Plate – 96-Well, Clear Styrene, 0.65 µm Hydrophilic PVDF

The Millipore MSDVN6510 is a premium 96-well MultiScreenHTS (High-Throughput Screening) filter plate engineered for automated liquid handling, whole-cell assays, bead-based assays, and clarifying particulate-heavy solutions. Molded from rigid, clear styrene, this plate features integrated, low-protein-binding Durapore® Hydrophilic PVDF membranes with a uniform 0.65 µm pore size. Optimized specifically for robotic workstations and vacuum manifolds, its advanced design isolates individual wells with specialized "drip directors" to effectively eliminate fluid wicking and cross-well contamination. A patented removable underdrain allows for direct access to the interior membranes, providing flexibility for downstream radioisotope detection, whole-organism visualization, or optical readout configurations.

Technical Performance and Design

• 0.65 µm Durapore® Membrane: The hydrophilic PVDF substrate yields exceptionally low non-specific protein and biomolecule binding while offering a larger 0.65 µm pore size, which provides faster flow rates and superior resistance to clogging when filtering dense cellular suspensions.

• Anti-Crosstalk Well Isolation: Individual well cavities feature independent under-seals. Coupled with proprietary drip directors, the plate forces fluids straight downward, preventing lateral tracking during aggressive vacuum or centrifugation steps.

• Rigid HTS High-Skirt Layout: Designed with reinforced, straight sidewalls that resist bending or twisting under robotic pressure. The smooth outer flange provides a large, uniform surface area ideal for automated barcode label placement.

• Removable Underdrain System: The defensive bottom plastic underdrain can be completely snapped off, exposing the underside of the PVDF discs for direct membrane harvesting, punch-out assays, or scintillation counting.

Product Specifications

• Catalog Number / MPN: MSDVN6510

• Product Family: MultiScreenHTS® (DV Filter Code)

• Format: 96-Well Standard Layout (8 × 12 Matrix)

• Housing Material: Clear Polystyrene (Styrene)

• Membrane Chemistry: Hydrophilic Polyvinylidene Fluoride (PVDF)

• Pore Size: 0.65 µm

• Volumetric Capacity: 50 µL to 250 µL Working Range (300 µL Maximum Headspace)

• Filtration Surface Area: 0.28 cm² per well

• Sterility: Non-Sterile

• Compliance: Fully conforms to ANSI/SLAS microplate architectural dimensional standards

Key Benefits & Applications

• Whole-Cell Sample Clarification: The standard choice for harvesting cells, processing yeast cultures, or clearing lysates where smaller 0.22 µm or 0.45 µm pores would prematurely foul or clog.

• Multiplex Bead-Based Assays: Highly effective for capturing large affinity resins, chromatographic beads, and multiplex microspheres while enabling rapid, high-volume wash buffer clearance.

• Radioisotope & Luminescence Assays: The removable underdrain facilitates direct membrane harvesting or punch-out protocols for downstream scintillation counting or microscopic inspection.

• Manifold and Centrifuge Processing: Fully operational on standard low-pressure vacuum manifolds (optimal vacuum pressure ~305 mbar) or inside multiwell swing-out plate centrifuges up to 1,000 × g.

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