Novasep Filter Cassette SIUS Prostream Low Binding PES 0.1 m2 300 kD

The Novasep PP300M01L Filter Cassette is a specialized Tangential Flow Filtration (TFF) module designed for the concentration and purification of large biomolecules in bioprocessing applications. This module is part of the ProStream series, known for its high performance and robust design.

A key feature of this cassette is its Polyethersulfone (PES) membrane with a 300 kD (300,000 Dalton) molecular weight cutoff (MWCO). The PES membrane is a high-flux, low-protein-binding material, which is ideal for minimizing sample loss and achieving high yields when processing large biological products like viruses or plasmids. The 300 kD MWCO is specifically chosen to retain large macromolecules while allowing smaller impurities to pass through.

The cassette has a large 0.1 m² filtration area, making it suitable for moderate to large-scale process development and pilot-scale purification runs. The SIUS (Single-Use) designation indicates that this is a fully disposable unit, eliminating the need for cleaning and cleaning validation, which significantly reduces process time and risk of cross-contamination in pharmaceutical manufacturing. This Novasep ProStream cassette is a vital tool for applications such as large molecule concentration, buffer exchange, and diafiltration in the biopharmaceutical industry.