Agilent HPLC Column Microsorb 60-8 C18 Dynamax Guard Sealed Package

Agilent R00083241G Microsorb 60-8 C18 Dynamax Guard Column – 8 µm, 41.4 mm ID

The Agilent R00083241G is a high-capacity preparative guard column engineered to extend the life and maintain the performance of Microsorb and Dynamax 41.4 mm ID primary HPLC columns. Featuring the 60-8 C18 stationary phase—a high-purity silica with an 8 micron particle size and a 60 Angstrom pore size—this guard column provides excellent retention of strongly adsorbed sample contaminants and particulates. Its robust 41.4 mm internal diameter (ID) is specifically designed for high-flow preparative applications, ensuring that protection is achieved without significant loss of resolution or excessive backpressure. By acting as a sacrificial barrier, the R00083241G prevents the irreversible fouling of expensive main columns, making it an essential component for cost-effective large-scale purification workflows.

Technical Performance and Design

• 60-8 C18 Packing Media: Utilizes 8 µm spherical silica particles with a 60 Å pore size, optimized for the high-resolution separation and protection of small molecules and peptides.

• Preparative Scale Protection: The 41.4 mm ID is engineered for high-throughput preparative HPLC, allowing for the processing of large sample loads while protecting the downstream stationary phase.

• Dynamax Hardware Integrity: Specifically designed to integrate seamlessly into the Dynamax hardware system, ensuring a leak-free, high-pressure seal and minimal extra-column volume.

• Extended Column Longevity: Effectively traps chemical "garbage" and mechanical debris from the mobile phase or sample matrix, significantly reducing the frequency of main column replacement or regeneration.

Product Specifications

• Catalog Number: R00083241G

• Stationary Phase: C18 (Octadecylsilane)

• Particle Size: 8 µm

• Pore Size: 60 Å

• Internal Diameter: 41.4 mm

• Length: 2 inches (approx. 50 mm)

• Hardware System: Dynamax

Key Benefits & Applications

• Preparative Purification: Ideal for pharmaceutical and natural product purification where large volumes of crude extract are loaded onto the column.

• Small Molecule Analysis: The 60 Å pore size is perfectly suited for the separation and protection of hydrophobic small molecules and small synthetic peptides.

• Cost Efficiency: By protecting a main column that can cost thousands of dollars, this guard column provides a high return on investment in busy production laboratories.

• High Chemical Stability: The C18 bonding chemistry is designed for stability across a wide pH range, ensuring consistent performance in diverse mobile phase conditions.

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