Alzet Brain Infusion Kit 3 1 - 3 mm Materials for 10 Infusions

Alzet 0008851 Brain Infusion Kit 3 – 1 to 3 mm Depth, 10 Infusions

The Alzet 0008851 Brain Infusion Kit 3 is a sterile, biocompatible cannula system engineered for targeted fluid delivery directly into the central nervous system (CNS) of small laboratory animals. Designed exclusively for integration with ALZET Osmotic Pumps, this kit enables continuous infusion into the cerebral ventricles or direct microperfusion of discrete brain structures, effectively bypassing the blood-brain barrier. Kit 3 features a 30-gauge stainless steel cannula with a maximum unadjusted penetration depth of 3 mm, making it the standard choice for targeting the lateral ventricles in adult mice. The inclusion of precision-molded polycarbonate spacers allows researchers to adjust the insertion depth from 1 mm to 3 mm in 0.5 mm increments.

Technical Performance and Design

• Customizable Penetration Depth: The kit includes 40 polycarbonate spacers (0.5 mm thickness each) that slide directly over the cannula tube, allowing researchers to precisely dictate the depth of the cannula tip within the brain tissue.

• Low-Profile Wide Base: The cannula features a wide polycarbonate base pedestal that provides excellent stability against the skull. The low-profile design facilitates easier skin closure after stereotaxic placement and frequently eliminates the need for separate anchor screws.

• Medical-Grade Biocompatibility: All components, including the stainless steel tubing, polycarbonate flanges, and polyvinylchloride (PVC) catheters, meet strict USP Class VI standards for biocompatibility to prevent tissue rejection or localized inflammation.

• Trauma-Minimizing Geometry: The ultra-fine 30-gauge stainless steel cannula minimizes trauma to delicate brain tissue during stereotaxic insertion compared to standard, thicker syringe needles.

Product Specifications

• Catalog Number: 0008851

• Cannula Gauge: 30 Gauge (ID: 0.16 mm / OD: 0.31 mm)

• Penetration Depth: 1 mm to 3 mm (adjustable via spacers)

• Materials: Stainless Steel (cannula), Polycarbonate (base/spacers), Medical-Grade PVC (tubing)

• System Compatibility: Compatible with all ALZET Osmotic Pump models

• Packaging: Materials for 10 complete infusions (10 Cannulae, 10 Catheters, 40 Spacers)

Key Benefits & Applications

• CNS Drug Delivery: Essential for administering neurotrophic factors, siRNA, peptides, and psychoactive drugs that do not readily cross the blood-brain barrier under normal physiological conditions.

• Mouse Models: The 3 mm unadjusted depth is anatomically optimized for stereotaxic targeting of the lateral ventricles in standard adult mouse models.

• Continuous Microperfusion: When paired with an ALZET pump, it provides reliable, round-the-clock dosing without the stress of repeated handling or the toxicity risks of acute injection spikes.

• Surgical Ready: The components arrive pre-sterilized via cobalt-60 radiation, allowing researchers to immediately prepare the assembly in a sterile field without manual autoclaving.

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