Corning Aseptic Transfer Cap 70 mm for 3 L Erlenmeyer Flask 4 Caps

Corning 431449 Aseptic Transfer Cap – 70 mm, for 3 L Erlenmeyer Flasks

The Corning 431449 is a premium, single-use aseptic transfer cap engineered to seamlessly convert standard 3-Liter plastic Erlenmeyer shake flasks into completely closed fluid-handling systems. Designed specifically for upstream bioprocessing and seed train expansion, this pre-assembled 70 mm threaded cap is equipped with dual ports to manage simultaneous gas venting and liquid transfer. Featuring a rigid internal dip tube, heat-sealable C-Flex tubing, and an industry-standard MPC quick-connect fitting, this sterilized assembly allows process engineers to safely add media, inoculate cultures, or harvest cells without ever exposing the flask contents to airborne laboratory contaminants.

Technical Performance and Design

• Angled Rigid Dip Tube: The internal polypropylene dip tube is precisely angled to reach the absolute bottom corner of a 3 L Erlenmeyer flask. This ensures maximum liquid recovery during cell harvesting, leaving virtually zero dead volume behind without the need to tilt the heavy vessel.

• 0.2 µm PVDF Vent Filter: The dedicated venting port is equipped with a large 50 mm diameter hydrophobic PVDF filter. This guarantees sterile gas displacement, actively preventing dangerous pressure buildup or vacuum collapse while fluid is being pumped in or out.

• Weldable C-Flex Tubing: The external fluid path utilizes 1/4-inch ID chemically resistant C-Flex tubing. Because it is a thermoplastic elastomer (TPE), technicians can use standard tube welders to fuse the line directly to bioreactor manifolds for a 100% closed-system transfer.

• MPC Quick Disconnect: For labs not using tube welders, the fluid line terminates in a Medical Grade Polycarbonate (MPC) male disconnect with a female sealing cap, allowing for rapid, secure, and tool-free mechanical connections to fluid routing manifolds.

Product Specifications

• Catalog Number: 431449

• Cap Size: 70 mm (Threaded)

• Flask Compatibility: 3 L Corning Plastic Erlenmeyer Flasks (PC/PETG)

• Tubing Type: C-Flex (1/4" ID x 3/8" OD)

• Terminal Fitting: MPC Male Disconnect

• Vent Filter: 50 mm diameter, 0.2 µm pore size

• Sterility: Single-Use, Sterile (10⁻⁶ SAL), Individually Double-Bagged

Key Benefits & Applications

• Seed Train Scale-Up: The absolute ideal assembly for transferring healthy cell cultures from a 3 L shake flask incubator directly into a benchtop or pilot-scale bioreactor while maintaining strict aseptic boundaries.

• Eliminates Hood Work: By providing a closed fluid path with MPC connections, operators can pump liquids directly on the laboratory bench top, completely freeing up valuable space and time inside crowded biological safety cabinets.

• Bypasses Cleaning Validation: Arriving double-bagged and gamma-irradiated, it eliminates the massive labor costs, autoclave cycles, and contamination risks associated with manually building and sterilizing reusable stainless-steel dip tube caps.

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