Cytiva Flange Tubing ID 1.2 mm x 420 mm FineLINE

Cytiva (GE) 18110220 Flanged Tubing – ID 1.2 mm x 420 mm, FineLINE

The Cytiva 18110220 (formerly GE Healthcare) is a precision-engineered flanged tubing assembly designed specifically for the FineLINE™ chromatography column series, particularly the FineLINE Pilot 35. This specialized tubing serves as a critical fluidic pathway for connecting columns to ÄKTA™ systems and other FPLC platforms. Featuring a narrow 1.2 mm internal diameter (ID) and a length of 420 mm, this tubing is optimized to minimize extra-column volume, which is essential for preserving the high resolution and peak symmetry of separations. The pre-flanged ends ensure a secure, hygienic, and leak-free connection, facilitating rapid system setup and maintaining the strict purity standards required for biopharmaceutical process development and pilot-scale manufacturing.

Technical Performance and Design

• Minimized Dead Volume: The 1.2 mm narrow bore is specifically selected to reduce residence time and peak broadening, ensuring that the high efficiency of the resin bed is fully realized in the final chromatogram.

• Hygienic Flanged Connections: The factory-flanged ends provide a smooth, internal flow path that eliminates "dead zones" where microbial growth or sample carryover could occur, meeting cGMP and sanitary design requirements.

• High-Purity Material Construction: Manufactured from medical-grade polymers, offering excellent chemical resistance to common chromatography solvents, buffers, and cleaning-in-place (CIP) reagents across a wide pH range.

• Optimal Pilot Scale Dimensions: At 420 mm in length, this tubing provides the necessary reach for convenient column placement within the system footprint while maintaining the compact fluidics necessary for high-performance purification.

Product Specifications

• Catalog Number: 18110220

• Internal Diameter (ID): 1.2 mm

• Length: 420 mm

• Material: High-purity Polypropylene / Fluoropolymer

• Compatibility: FineLINE™ Pilot 35 Columns; ÄKTA™ chromatography systems.

• Connection Type: Pre-flanged ends for M6 or specialized chromatography fittings.

• Operating Pressure: Engineered to withstand standard FPLC and Pilot-scale operating pressures.

Key Benefits & Applications

• Process Development & Scale-Up: A standard component for the FineLINE Pilot 35, enabling direct and predictable scale-up from lab-scale columns to industrial production.

• Oligonucleotide and Protein Purification: Compatible with both aqueous buffers and organic solvent environments used in specialized column configurations.

• Streamlined Maintenance: The pre-cut and pre-flanged design allows for immediate replacement without the need for manual flanging tools, ensuring consistent quality and system uptime.

• Validated Workflows: Supports the high standards of hygiene and traceability required for the manufacturing of vaccines, monoclonal antibodies, and recombinant proteins.

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