Cytiva GE 18110216 Glass Tube FineLINE Pilot 35

Cytiva 18110216 Glass Tube for FineLINE™ Pilot 35 Chromatography Column

The Cytiva 18110216 is a precision-engineered replacement glass tube designed exclusively for the FineLINE™ Pilot 35 chromatography column. Manufactured from high-clarity, calibrated borosilicate glass, this tube forms the central body of the column where the resin bed is packed. The Pilot 35 system is the standard for method development and scale-up optimization, and this glass construction is vital for providing 360-degree visibility of the bed. This allows researchers to visually verify packing uniformity, monitor for air bubbles, and observe sample migration in real-time. Engineered to withstand medium-pressure applications (up to 20 bar), this tube ensures dimensional stability and chemical resistance across a wide range of biopharmaceutical purification workflows.

Technical Performance and Design

• Calibrated Borosilicate Glass: Unlike standard laboratory glassware, this tube is precision-calibrated to maintain a strict 35 mm internal diameter (ID). This ensures uniform flow distribution and consistent linear velocity across the entire resin bed.

• Medium Pressure Capability: While made of glass, the 18110216 is designed to handle the high-performance requirements of SOURCE™ 15 and SOURCE™ 30 resins, with a design pressure rating of up to 2 MPa (20 bar / 290 psi).

• Exceptional Chemical Resistance: Borosilicate glass offers nearly universal compatibility with the harsh solvents and high-molarity salts used in ion exchange (IEX), hydrophobic interaction (HIC), and reversed-phase chromatography (RPC).

• Optical Process Monitoring: The high-clarity surface allows for the immediate detection of bed cracks, channeling, or headspace gaps, preventing compromised runs and ensuring reproducible pilot-scale results.

Product Specifications

• Catalog Number: 18110216 (Old GE Code: 18-1102-16)

• Internal Diameter (ID): 35 mm

• Max Inner Length: 330 mm

• Material: Calibrated Borosilicate Glass

• Design Pressure: 2 MPa (20 bar, 290 psi)

• Operating Temperature: 4°C to 40°C

• Compatibility: Specifically for FineLINE™ Pilot 35 and FineLINE™ 35 Oligo columns.

Key Benefits & Applications

• Method Development: The smallest in the FineLINE family, this 35mm tube is the primary tool for downscaling from large production columns to optimize resin use and flow parameters.

• Oligonucleotide Synthesis: Frequently used with the ÄKTA oligosynt™ system, providing the chemical durability required for the organic solvents used in solid-phase DNA/RNA synthesis.

• High-Resolution Separations: Optimized for use with fine-particle resins (15–30 µm), where the rigidity and precision of the calibrated tube are necessary to maintain a stable, high-efficiency bed.

• Hygienic Design: The smooth, non-porous glass surface prevents protein carryover and is easily sanitized with standard NaOH protocols, supporting the high standards of biopharmaceutical production.

All product names, logos, and brands are property of their respective owners. FineLINE and SOURCE are trademarks of Cytiva (Global Life Sciences Solutions USA LLC).