Cytiva GE Xampler Ultrafiltration Hollow Fiber Cartridge UFP-300-C-4x2MA

Cytiva (GE) UFP-300-C-4x2MA Xampler Ultrafiltration Hollow Fiber Cartridge

The Cytiva UFP-300-C-4x2MA is a laboratory-scale hollow fiber cartridge engineered for the rapid concentration and diafiltration of biological solutions. Featuring a 300,000 NMWC (Nominal Molecular Weight Cutoff) polysulfone membrane, this cartridge provides high product recovery with minimal shear stress, making it ideal for the processing of sensitive proteins, vaccines, and large biomolecules. The "4x2MA" configuration offers a 60 cm flow path length and a 1,400 cm² surface area, providing a reliable linear scale-up path to larger process-scale systems. Equipped with sanitary 0.5" Tri-Clamp connections, the UFP-300-C-4x2MA ensures easy, leak-proof integration into ÄKTA systems, QuixStand benchtop units, and other TFF platforms.

Technical Performance and Design

• 300k NMWC Polysulfone Membrane: The proprietary polysulfone fiber structure is optimized for high flux and low non-specific protein binding, ensuring maximum yield even with complex biological feedstocks.

• Linear Scalability: The 60 cm (24 inch) path length matches the geometry of Cytiva’s pilot and production-scale cartridges, allowing for predictable performance during process development and tech transfer.

• Sanitary Tri-Clamp Connections: Features 0.5" Tri-Clamp (TC) ports for feed and retentate, facilitating secure, aseptic connections that meet the rigorous standards of cGMP laboratory environments.

• Low Shear Processing: The hollow fiber geometry provides a gentle "open-channel" flow path, significantly reducing the mechanical stress on delicate cells or proteins compared to traditional plate-and-frame TFF systems.

Product Specifications

• Catalog Number: 56-4102-16 (UFP-300-C-4x2MA)

• Membrane Cutoff (MWCO): 300,000 NMWC

• Membrane Surface Area: 1,400 cm² (1.5 ft²)

• Fiber Internal Diameter (ID): 0.5 mm

• Flow Path Length: 60 cm (24 inches)

• Materials: Polysulfone fibers and housing; Epoxy potting; Polypropylene support net.

• Autoclavable: Yes (Up to 121°C)

Key Benefits & Applications

• Biomolecule Concentration: Ideal for the rapid concentration of monoclonal antibodies, enzymes, and recombinant proteins while maintaining biological activity.

• Diafiltration & Buffer Exchange: Enables efficient removal of salts, solvents, and small-molecule contaminants in a continuous or batch-mode process.

• Virus & Vaccine Processing: The 300k MWCO is well-suited for the clarification and concentration of large viruses and viral vectors used in gene therapy.

• Process Optimization: The Xampler series allows researchers to optimize TFF parameters (shear rate, TMP, and flux) at the 1L to 5L scale before moving to industrial production.

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