Hamilton Gas-tight Syringe 1000 ul Glass Compatible with Avanti Extruder

Hamilton 0200166 Gastight Syringe – 1000 µL, Avanti Mini-Extruder Compatible

The Hamilton 0200166 (Avanti SKU 610017) is a premium 1000 µL Gastight syringe engineered specifically for high-pressure fluid handling and lipid extrusion workflows. Built upon the proven Hamilton 1001 RN model, this syringe utilizes a chemically inert, precision-machined PTFE plunger tip that creates an interference fit within the borosilicate glass barrel. This gas-tight seal guarantees that high-value fluid samples will not blow by the plunger, even when subjected to the extreme manual force required during liposome sizing. The syringe is equipped with a Removable Needle (RN) termination, allowing it to securely seat the specialized ~0.5-inch needles required to interface with the Avanti Mini-Extruder block. Due to its rugged construction and chemical resilience, it is an essential tool for membrane biophysics, nanoparticle formulation, and drug delivery research.

Technical Performance and Design

• Gastight PTFE Plunger: The self-lubricating PTFE tip ensures highly reproducible fluid delivery and completely prevents sample loss or leakage, which is crucial when manually pushing viscous lipid matrices through sub-micron filters.

• Removable Needle (RN) Termination: Designed to securely hold precision needles while allowing for rapid replacement. If a needle bends or clogs during aggressive extrusion, it can be swapped out without discarding the expensive glass syringe body.

• Borosilicate Glass Barrel: The premium glass construction provides exceptional thermal shock resistance and broad chemical compatibility, allowing researchers to safely use harsh organic solvents like chloroform or methanol.

• High-Pressure Integrity: The 1 mL volume and structural geometry are perfectly matched to the mechanical requirements of the Avanti Mini-Extruder, ensuring smooth, continuous strokes during lipid formulation.

Product Specifications

• Catalog Number: 0200166 (Avanti SKU: 610017)

• Base Model: Hamilton 1001 RN (1000 Series)

• Capacity: 1000 µL (1 mL)

• Syringe Type: Gastight (PTFE-tipped plunger)

• Barrel Material: Borosilicate Glass

• Termination: RN (Removable Needle)

Key Benefits & Applications

• Liposome Extrusion: The required replacement syringe for the Avanti Mini-Extruder, essential for generating Large Unilamellar Vesicles (LUVs) with tight, uniform size distributions.

• Maximized Sample Recovery: The flawless PTFE seal ensures that researchers can recover nearly 100% of expensive, highly concentrated lipid or mRNA-LNP formulations.

• Analytical Standard Prep: Beyond extrusion, the extreme accuracy of the 1001 RN makes it highly valuable for standard GC/HPLC injection and general mid-range micro-volume pipetting.

• Cost-Effective Maintenance: The modular design of the RN hub lowers the long-term cost of ownership, as the needle and the glass barrel can be maintained or replaced independently.

All product names, logos, and brands are property of their respective owners.