Pall Base Manifold System 125 ml Compatible with Allegro System

Pall 6415-0474M Base Manifold System – 125 mL, Allegro Compatible

The Pall 6415-0474M is a premium, single-use base addition manifold engineered to facilitate precise, aseptic fluid transfers in demanding bioprocessing environments. Designed specifically for compatibility with Allegro liquid management systems and iCELLis Nano bioreactors, this 125 mL capacity manifold acts as the vital, sterile bridge for introducing pH titrants or concentrated feeds into active cell cultures. Constructed utilizing high-purity, platinum-cured silicone tubing and medical-grade MPC quick-connectors, it guarantees exceptional fluid integrity and virtually zero extractables. Arriving pre-sterilized and fully assembled, this closed-system manifold completely eliminates the need for manual tubing assembly, immediately streamlining your upstream process development and small-scale manufacturing workflows.

Technical Performance and Design

• Optimized for Base Titration: Specifically designed to handle the aseptic, slow-drip addition of basic solutions required for continuous bioreactor pH control, protecting delicate mammalian cells from sudden chemical shock or environmental contamination.

• Platinum-Cured Silicone Tubing: The fluid path is constructed entirely of biopharmaceutical-grade, platinum-cured silicone, ensuring maximum flexibility, excellent pump-head durability (if routed through a peristaltic pump), and an ultra-low extractable profile.

• Secure MPC Connectors: Equipped with industry-standard medical polycarbonate (MPC) quick-connectors that snap together securely. This allows technicians to make rapid, leak-proof connections to media bags and bioreactor ports without the need for cumbersome tube welding.

• True Single-Use Efficiency: By utilizing a completely disposable manifold, facilities bypass the massive pure water, labor, and validation costs associated with traditional stainless steel Clean-in-Place (CIP) and Sterilize-in-Place (SIP) routines.

Product Specifications

• Catalog Number: 6415-0474M

• Product Line: Pall Single-Use Systems (Cytiva)

• System Type: Base Addition Manifold

• Nominal Capacity: 125 mL

• Tubing Material: Platinum-Cured Silicone

• Fittings: MPC Connectors

• System Compatibility: Allegro Systems, iCELLis Nano Bioreactors

Key Benefits & Applications

• Automated pH Control: The ideal fluid routing solution for connecting a base-buffer supply bag directly to a bioreactor's automated titration pump during prolonged viral vector or recombinant protein production runs.

• Upstream Bioprocessing: Beyond pH control, the 125 mL volume makes it an excellent conduit for small-scale, precision nutrient feeding or anti-foam additions in benchtop cell cultures.

• Plug-and-Play Integration: The standardized MPC fittings ensure that this manifold can be deployed immediately out of the package, drastically reducing setup time and minimizing operator handling errors.

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