Phenomenex Strata Microplate 25 mg C18-E 96 Well 2 Sealed Plates

Phenomenex Strata C18-E SPE Microplate – 25 mg/well, Reversed Phase, 96-Well

The Phenomenex 8E-S001-CGB is a high-performance Solid Phase Extraction (SPE) microplate engineered for the rapid, high-throughput isolation of hydrophobic and moderately polar compounds. Each well in the 96-well polypropylene manifold contains 25 mg of Strata C18-E, a 55 µm silica-based reversed-phase sorbent. Featuring a densely bonded octadecyl carbon chain, this sorbent relies on strong hydrophobic interactions to pull target analytes out of aqueous sample matrices. Crucially, the "E" designation indicates that the silica has been aggressively endcapped. This manufacturing process caps active surface silanols, completely preventing the secondary ionic interactions that typically cause basic compounds to bind irreversibly to standard C18 silica. The highly efficient 25 mg sorbent mass is explicitly optimized for smaller sample volumes, allowing researchers to utilize highly concentrated, low-volume elution steps that often bypass the need for solvent evaporation before LC-MS/MS injection.

Technical Performance and Design

• Endcapped C18 Chemistry: The dense endcapping neutralizes acidic silanol groups on the silica backbone, preventing basic analytes from tailing or sticking, ensuring maximum recovery and clean chromatographic profiles.

• Strong Hydrophobic Retention: The traditional reversed-phase mechanism is universally effective for extracting a vast library of neutral and non-polar compounds, making it an excellent starting point for general SPE method development.

• Low Bed Weight (25 mg): The efficient 25 mg sorbent mass is optimized for smaller biological sample sizes, allowing researchers to minimize elution solvent volumes and speed up overall processing times.

• High-Throughput 96-Well Format: Built into a standard SBS-footprint polypropylene plate, making it seamlessly compatible with automated liquid handling robots, positive pressure manifolds, and 96-well vacuum blocks for rapid batch processing.

Product Specifications

• Catalog Number: 8E-S001-CGB

• Format: 96-Well Plate

• Phase/Chemistry: Strata C18-E (Silica-Based Endcapped Octadecyl)

• Particle Size: 55 µm (70 Å Pore Size)

• Sorbent Mass: 25 mg per well

• Housing Material: Polypropylene

• Target Analytes: Hydrophobic, Neutral, and Moderately Polar Compounds

Key Benefits & Applications

• Broad-Spectrum Extraction: The gold standard for routine extraction and desalting of pharmaceuticals, environmental pollutants, and endogenous biomolecules from complex aqueous matrices.

• Clinical & Toxicological Assays: Highly effective for cleaning up blood plasma, serum, and urine samples prior to HPLC or GC-MS analysis.

• Low-Volume Efficiency: Perfect for high-throughput diagnostic assays where biological sample volumes are limited and rapid processing is required.

• Proven Silica Reliability: Offers predictable, historically validated retention characteristics that seamlessly adapt to legacy USP and EPA testing monographs.

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