Phenomenex Strata Microplate 96 Well C18-E 55 um 50 mg Each Well 2 Plates

Phenomenex Strata C18-E SPE Microplate – 50 mg/well, Reversed Phase, 96-Well

The Phenomenex 8E-S001-DGB is a high-performance Solid Phase Extraction (SPE) microplate engineered for the rapid, high-throughput isolation of hydrophobic and moderately polar compounds. Each well in the 96-well polypropylene manifold contains 50 mg of Strata C18-E, a 55 µm silica-based reversed-phase sorbent. Featuring a densely bonded octadecyl carbon chain, this sorbent relies on strong hydrophobic interactions to pull target analytes out of aqueous sample matrices. Crucially, the "E" designation indicates that the silica has been aggressively endcapped. This manufacturing process caps active surface silanols, completely preventing the secondary ionic interactions that typically cause basic compounds to bind irreversibly to standard C18 silica. The robust 50 mg sorbent mass provides increased binding capacity, making it ideal for processing larger sample volumes or heavily concentrated matrixes without the risk of analyte breakthrough.

Technical Performance and Design

• Endcapped C18 Chemistry: The dense endcapping neutralizes acidic silanol groups on the silica backbone, preventing basic analytes from tailing or sticking, ensuring maximum recovery and clean chromatographic profiles.

• Strong Hydrophobic Retention: The traditional reversed-phase mechanism is universally effective for extracting a vast library of neutral and non-polar compounds, making it an excellent starting point for general SPE method development.

• Increased Bed Weight (50 mg): The higher 50 mg sorbent capacity ensures that the silica bed will not easily overload, providing exceptional recovery for larger sample aliquots or biological matrices containing high levels of target analytes.

• High-Throughput 96-Well Format: Built into a standard SBS-footprint polypropylene plate, making it seamlessly compatible with automated liquid handling robots, positive pressure manifolds, and 96-well vacuum blocks for rapid batch processing.

Product Specifications

• Catalog Number: 8E-S001-DGB

• Format: 96-Well Plate

• Phase/Chemistry: Strata C18-E (Silica-Based Endcapped Octadecyl)

• Particle Size: 55 µm (70 Å Pore Size)

• Sorbent Mass: 50 mg per well

• Housing Material: Polypropylene

• Target Analytes: Hydrophobic, Neutral, and Moderately Polar Compounds

Key Benefits & Applications

• Broad-Spectrum Extraction: The gold standard for routine extraction and desalting of pharmaceuticals, environmental pollutants, and endogenous biomolecules from complex aqueous matrices.

• Clinical & Toxicological Assays: Highly effective for cleaning up blood plasma, serum, and urine samples prior to HPLC or GC-MS analysis.

• High-Capacity Processing: The 50 mg format is perfect for workflows that require concentrating trace levels of analytes from larger sample volumes without compromising retention.

• Proven Silica Reliability: Offers predictable, historically validated retention characteristics that seamlessly adapt to legacy USP and EPA testing monographs.

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