Phenomenex Strata Microplate C8 96-Well 25 mg Sorbent

Phenomenex Strata C8 SPE Microplate – 25 mg/well, Reversed Phase, 96-Well

The Phenomenex 8E-S005-CGB is a high-performance Solid Phase Extraction (SPE) microplate engineered for the rapid, high-throughput isolation of extremely hydrophobic and moderately polar compounds. Each well in the 96-well polypropylene manifold contains 25 mg of Strata C8, a 55 µm silica-based reversed-phase sorbent. Featuring an octyl carbon chain, this sorbent relies on hydrophobic interactions to pull target analytes out of aqueous sample matrices. Because the 8-carbon chain is shorter than a traditional 18-carbon phase, it exerts less retention force, ensuring that highly lipophilic analytes can be eluted off the sorbent using less aggressive solvent conditions. The highly efficient 25 mg sorbent mass is explicitly optimized for smaller sample volumes, allowing researchers to utilize highly concentrated, low-volume elution steps that often bypass the need for solvent evaporation before LC-MS/MS injection.

Technical Performance and Design

• C8 (Octyl) Chemistry: The 8-carbon alkyl chain provides a moderate reversed-phase retention mechanism, offering faster elution and higher overall recoveries for heavily lipophilic or extremely hydrophobic compounds compared to standard C18 silica.

• High-Purity Silica Backbone: The 55 µm particle size and 70 Å pore size offer highly reproducible flow rates, maximizing the surface area for rapid binding without clogging under standard vacuum or positive pressure.

• Low Bed Weight (25 mg): The highly efficient 25 mg sorbent mass is optimized for smaller biological sample sizes, allowing researchers to minimize elution solvent volumes and speed up overall processing times.

• High-Throughput 96-Well Format: Built into a standard SBS-footprint polypropylene plate, making it seamlessly compatible with automated liquid handling robots, positive pressure manifolds, and 96-well vacuum blocks for rapid batch processing.

Product Specifications

• Catalog Number: 8E-S005-CGB

• Format: 96-Well Plate

• Phase/Chemistry: Strata C8 (Silica-Based Octyl)

• Particle Size: 55 µm (70 Å Pore Size)

• Sorbent Mass: 25 mg per well

• Housing Material: Polypropylene

• Target Analytes: Extremely Hydrophobic, Neutral, and Moderately Polar Compounds

Key Benefits & Applications

• Hydrophobic Analyte Recovery: The absolute best choice for isolating highly lipophilic compounds (like fat-soluble vitamins, heavy steroids, or non-polar environmental toxins) that are otherwise difficult to elute from densely packed C18 columns.

• Clinical & Toxicological Assays: Highly effective for cleaning up blood plasma, serum, and urine samples prior to HPLC or GC-MS analysis.

• Low-Volume Efficiency: Perfect for high-throughput diagnostic assays where biological sample volumes are limited and rapid processing is required.

• Proven Silica Reliability: Offers predictable, historically validated retention characteristics that seamlessly adapt to legacy USP and EPA testing monographs.

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