Phenomenex Strata-X-AW Microplate 60 mg Weak Anion 96 Well 2 Plates

Phenomenex Strata-X-AW SPE Microplate – 60 mg/well, Weak Anion, 96-Well

The Phenomenex 8E-S038-UGB is a high-performance Solid Phase Extraction (SPE) microplate engineered for the rapid, high-throughput isolation of acidic compounds. Each well in the 96-well polypropylene manifold contains 60 mg of Strata-X-AW, a 33 µm polymeric weak anion-exchange sorbent. Unlike traditional silica-based sorbents, this rugged polymeric backbone resists deconditioning if accidentally dried under vacuum, guaranteeing consistent recovery rates. The mixed-mode chemistry tightly retains strong acids (pKa < 5), allowing researchers to utilize highly aggressive, 100% organic wash solutions to flush out stubborn matrix interferences before final elution. This results in ultra-clean extracts that significantly improve LC-MS/MS sensitivity and drastically extend the lifespan of analytical chromatography columns.

Technical Performance and Design

• Mixed-Mode Retention: Synergistically combines weak anion-exchange capabilities with reversed-phase (hydrophobic and pi-pi) bonding, providing unparalleled selectivity and retention for strongly acidic analytes.

• 100% Organic Wash Capability: The strong ionic binding of target acids enables the use of 100% organic solvents during the wash step, effectively stripping away neutral and basic interferences, phospholipids, and particulates.

• High-Throughput 96-Well Format: Built into a standard SBS-footprint polypropylene plate, making it seamlessly compatible with automated liquid handling robots, positive pressure manifolds, and standard vacuum blocks for rapid batch processing.

• 33 µm Polymeric Particle: The highly uniform particle size provides excellent flow characteristics and a massive surface area, resulting in highly reproducible extractions, concentrated analyte recoveries, and zero channeling effects.

Product Specifications

• Catalog Number: 8E-S038-UGB

• Format: 96-Well Plate

• Phase/Chemistry: Strata-X-AW (Polymeric Weak Anion Mixed Mode)

• Particle Size: 33 µm

• Sorbent Mass: 60 mg per well

• Housing Material: Polypropylene

• Target Analytes: Strong Acids (pKa < 5)

Key Benefits & Applications

• Clinical & Toxicological Assays: The industry standard for the high-throughput extraction of strongly acidic drugs, metabolites, and biomarkers from complex biological fluids like plasma, serum, and urine.

• Environmental Testing: Highly effective for concentrating trace-level acidic contaminants, such as perfluoroalkyl substances (PFAS) or acidic herbicides, from municipal water and soil extracts.

• Solvent Switching & Concentration: Allows researchers to elute target compounds directly into a minimal volume of mass-spec friendly solvent, bypassing time-consuming evaporation and reconstitution steps.

• Robust Method Reliability: The advanced polymeric backbone prevents the sorbent from drying out, ensuring that accidental drying during processing will not compromise sensitive extraction recoveries.

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