{"product_id":"corning-3471-costar-microplate-6-well-ultra-low-attachment-surface-16-8-ml-polystyrene","title":"Corning 3471 Costar Microplate 6 Well Ultra-Low Attachment Surface 16.8 ml Polystyrene Case of 24 Plates","description":"\u003ch3\u003eCorning® Costar® 6-Well Clear Flat-Bottom Ultra-Low Attachment (ULA) Microplates with Lids (3471) – Case of 24\u003c\/h3\u003e\n\u003cp\u003eThe Corning® Costar® 3471 is a specialized, research-grade multi-well plate engineered for the generation and expansion of 3D multicellular tumor spheroids (MCTS), embryoid bodies, organoids, and primary stem cell aggregates. Precision-molded from high-purity virgin polystyrene, each plate features a 6-well configuration with an optically clear, flat-bottom base. The interior growth surface of each well is permanently modified with a covalently bound, hydrophilic, neutrally charged Ultra-Low Attachment (ULA) hydrogel layer. This hydrogel coating minimizes non-specific protein adsorption, completely preventing anchorage-dependent cell lines from grounding, flattening, or initiating surface-mediated differentiation. Supplied as a commercial case of 24 individually wrapped plates with matching lids, this model delivers absolute aseptic performance for advanced oncology, immunology, and stem cell bioprocessing cleanrooms.\u003c\/p\u003e\n\u003ch3\u003eTechnical Performance \u0026amp; Surface Chemistry\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCovalently Bound Hydrogel Layer: Features a stable, ultra-thin hydrogel matrix cross-linked to the polystyrene well bottom. This non-ionic, neutral barrier suppresses the adsorption of key serum attachment proteins (such as fibronectin and vitronectin), effectively neutralizing cell-to-plastic adhesion forces.\u003c\/li\u003e\n\u003cli\u003e3D Spheroid \u0026amp; Aggregate Optimization: By denying a physical grounding plane, cells are maintained in a continuous suspension state. This forces natural cell-to-cell signaling loops, promoting the spontaneous self-assembly of uniform 3D spheroids and suspension clusters.\u003c\/li\u003e\n\u003cli\u003eInverted Optical Clarity Profile: Precision injection-molded flat well bases provide a uniform, thin optical window with low background autofluorescence. This layout ensures crisp, distortion-free focal planes during high-resolution phase-contrast or inverted fluorescence microscopy tracking.\u003c\/li\u003e\n\u003cli\u003eCondensation-Control Non-Reversible Lid: The included clear polystyrene lid incorporates dedicated condensation rings matching the 6-well matrix. This design ensures safe gas exchange while minimizing localized evaporation rates and preventing cross-contamination across adjacent wells.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eProduct Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCatalog Number \/ MPN: 3471\u003c\/li\u003e\n\u003cli\u003ePrimary Manufacturer: Corning Life Sciences (Costar® Product Family)\u003c\/li\u003e\n\u003cli\u003ePlate Format Configuration: 6-Well Multi-Well Matrix (2 x 3 Array)\u003c\/li\u003e\n\u003cli\u003eWell Bottom Profile: Flat-Bottom Geometry (Optimized for microscopy and automated high-resolution scanning)\u003c\/li\u003e\n\u003cli\u003eSurface Chemistry: Ultra-Low Attachment (ULA) Hydrogel Coating (Neutrally charged, non-ionic surface profile)\u003c\/li\u003e\n\u003cli\u003eMaterial Composition: Optical-grade, USP Class VI virgin polystyrene (Latex-free \/ Silicone-free)\u003c\/li\u003e\n\u003cli\u003eTotal Well Volume Capacity: Nominal 16.8 mL per well\u003c\/li\u003e\n\u003cli\u003eRecommended Working Volume: 1.9 mL to 2.9 mL per well\u003c\/li\u003e\n\u003cli\u003eCell Growth Base Area: Nominal 9.5 cm² per well\u003c\/li\u003e\n\u003cli\u003eSterility \u0026amp; Purity Status: Gamma-irradiation sterilized (SAL $10^{-6}$ baseline); Certified Non-Pyrogenic and Non-Cytotoxic\u003c\/li\u003e\n\u003cli\u003ePackaging Configuration: Case of 24 Plates with Lids (Each plate individually wrapped in an easy-to-peel medical-grade aseptic pouch)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eKey Benefits \u0026amp; Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTumor Spheroid and Organoid Cultivation: The industry benchmark platform for generating consistent 3D tumor models directly from primary tumor tissues or established cancer cell lines for high-accuracy drug screening.\u003c\/li\u003e\n\u003cli\u003eStem Cell Maintenance: Prevents early, surface-mediated differentiation of human pluripotent stem cells (hPSCs\/iPSCs), maintaining stemness markers during early cluster expansion or multi-lineage differentiation staging.\u003c\/li\u003e\n\u003cli\u003eAutomation and Robotic Stacking: Built to meet universal ANSI\/SLAS footprint standard specifications, ensuring smooth, jam-free integration with automated microplate washers, liquid handlers, and robotic incubator tracks.\u003c\/li\u003e\n\u003cli\u003e**Lot-Specific Compliance Tracking:** Every sterile blister pouch has the master manufacturing lot code and expiration metric printed directly on the exterior liner to facilitate cleanroom auditing and institutional inventory compliance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eExpiration Date 2025-11-02\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003csmall\u003eCorning® and Costar® are registered commercial trademarks of Corning, Inc. Catalog number 3471 specifies the flat-bottom, Ultra-Low Attachment 6-well setup provided with a lid. For routine attachment-dependent cell cultures or standard monolayer expansion workflows, companion tissue culture-treated (TC) multi-well configurations (such as Costar SKU 3516) must be selected instead.\u003c\/small\u003e\u003c\/p\u003e","brand":"Corning","offers":[{"title":"Default Title","offer_id":49256435843324,"sku":"6044","price":308.75,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0627\/8463\/5132\/files\/IMG_4548_Shopify1024.jpg?v=1783369829","url":"https:\/\/lifesciencestrading.com\/es\/products\/corning-3471-costar-microplate-6-well-ultra-low-attachment-surface-16-8-ml-polystyrene","provider":"Life Sciences Trading","version":"1.0","type":"link"}