{"product_id":"repligen-midikros-hollow-fiber-filter-20-cm-length-0-65-um-mpes-0-75-mm-fll-x-fll","title":"Repligen MidiKros Hollow Fiber Filter 20 cm Length 0.65 um MPES 0.75 mm FLL X FLL","description":"\u003ch3\u003eRepligen MidiKros Hollow Fiber Filter, 20 cm Length, 0.65 µm mPES, 0.75 mm ID, FLL x FLL (D02-E65U-07-N)\u003c\/h3\u003e\n\u003cp\u003eThe Repligen MidiKros Hollow Fiber Filter (D02-E65U-07-N) is a high-performance single-use tangential flow filtration (TFF) module engineered for pilot-scale, benchtop, and clinical bioprocessing applications. Featuring a 0.65 µm pore size microfiltration membrane composed of modified Polyethersulfone (mPES), this filter delivers superior flux rates, low protein binding, and high volumetric throughput during cell clarification, lysate harvesting, and particle separation workflows. Designed with a 20 cm active path length and 0.75 mm lumen inner diameter (ID) fibers, the module balances shear rate optimization with efficient fluid dynamics. Encapsulated in a clear polysulfone housing with standard Female Luer Lock (FLL) process and permeate port connections, the MidiKros module seamlessly integrates into automated or manual TFF assemblies, providing predictable linear scale-up to larger process-scale filtration systems while eliminating cleaning validation and cross-contamination risks.\u003c\/p\u003e\n\u003ch3\u003eTechnical Performance \u0026amp; Structural Attributes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAdvanced mPES Membrane Chemistry: Hydrophilized modified Polyethersulfone provides low non-specific binding, excellent chemical resistance across a broad pH range, and minimized fouling tendencies during dense cell harvests.\u003c\/li\u003e\n\u003cli\u003eOptimized Hollow Fiber Lumen Dimensions: 0.75 mm inner diameter fiber geometry offers an optimal balance between low shear stress on shear-sensitive mammalian or microbial cells and low cross-flow pumping requirements.\u003c\/li\u003e\n\u003cli\u003eModular Single-Use Construction: Pre-assembled, potted, and housing-encapsulated design eliminates manual membrane mounting, cartridge cleaning, and water-for-injection (WFI) flushing validation.\u003c\/li\u003e\n\u003cli\u003eStandardized Luer Lock Connection Ports: Configured with Female Luer Lock (FLL) fittings on both feed\/retentate flow-through channels and side permeate ports for secure, leak-free connection to flexible bioprocess tubing circuits.\u003c\/li\u003e\n\u003cli\u003eLinear Bioprocess Scalability: Identical fluid flow channel height and membrane properties allow direct, reliable scale-up to larger KrosFlo and MaxiKros hollow fiber module formats.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eProduct Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCatalog \/ Part Number: D02-E65U-07-N\u003c\/li\u003e\n\u003cli\u003ePrimary Manufacturer: Repligen Corporation\u003c\/li\u003e\n\u003cli\u003eFilter Module Series: MidiKros Hollow Fiber Module\u003c\/li\u003e\n\u003cli\u003eMembrane Material: Modified Polyethersulfone (mPES)\u003c\/li\u003e\n\u003cli\u003ePore Size Rating: 0.65 µm (Microfiltration)\u003c\/li\u003e\n\u003cli\u003eFiber Inner Diameter (ID): 0.75 mm\u003c\/li\u003e\n\u003cli\u003eActive Module Path Length: 20 cm\u003c\/li\u003e\n\u003cli\u003eFeed \/ Retentate Connections: Female Luer Lock (FLL)\u003c\/li\u003e\n\u003cli\u003ePermeate Port Connections: Female Luer Lock (FLL)\u003c\/li\u003e\n\u003cli\u003eHousing Material: Polysulfone (PSU), USP Class VI Compliant\u003c\/li\u003e\n\u003cli\u003eRegulatory Compliance: USP Class VI, ISO 10993, Gamma Irradiated \/ Autoclavable, Non-Pyrogenic\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eKey Benefits \u0026amp; Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCell Clarification \u0026amp; Bioreactor Harvesting: Ideal for continuous or batch removal of intact mammalian cells (CHO, HEK293) and cell debris from culture broths without centrifugation.\u003c\/li\u003e\n\u003cli\u003eBacterial \u0026amp; Yeast Lysate Separation: Efficiently separates recombinant target proteins from dense bacterial lysates (e.g., \u003ci\u003eE. coli\u003c\/i\u003e) prior to downstream chromatography purification steps.\u003c\/li\u003e\n\u003cli\u003eMicrobial \u0026amp; Viral Suspension Concentration: Provides gentle, low-shear microfiltration for concentrating large viral vectors, liposomes, and extracellular vesicles (EVs).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003cp\u003e\u003csmall\u003eAll product names, logos, and brands are property of their respective owners. Repligen, MidiKros, KrosFlo, and MaxiKros are registered trademarks of Repligen Corporation.\u003c\/small\u003e\u003c\/p\u003e","brand":"Repligen","offers":[{"title":"Default Title","offer_id":67719649132796,"sku":"11019","price":190.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0627\/8463\/5132\/files\/repligen-midikros-hollow-fiber-filter-20-cm-length-065-um-mpes-075-mm-fll-x-fll-filters-repligen-177888.jpg?v=1792095824","url":"https:\/\/lifesciencestrading.com\/es\/products\/repligen-midikros-hollow-fiber-filter-20-cm-length-0-65-um-mpes-0-75-mm-fll-x-fll","provider":"Life Sciences Trading","version":"1.0","type":"link"}