Millipore Millistak Pod Depth Filter 23 cm2 4 Filters

Millipore MDE3023CL3 Millistak+ uPod Depth Filter (DE30 Media, 23 cm2)

The Millipore MDE3023CL3 is a specialized depth filtration device engineered for small-scale process development and primary clarification trials. Utilizing the DE30 media grade, this filter combines high-purity cellulose with Diatomaceous Earth (DE) and an electropositive charged resin. The DE30 grade features a more open pore structure compared to finer DE-series filters, making it optimized for the removal of whole cells and large cellular debris from high-turbidity harvests. The uPod format offers a 23 cm2 filtration area, providing a reliable benchtop model for predicting the performance of large-scale Millistak+ HC Pod systems while significantly reducing the volume of expensive biological feedstreams required for testing.

Technical Performance and Design

• DE30 Coarse High-Capacity Media: Engineered as a primary clarification workhorse, the DE30 grade handles high solids concentrations effectively, preventing premature surface blinding and extending filter life in demanding feedstreams.

• Adsorptive Sequestration: The inclusion of charged resin provides an electropositive surface that captures negatively charged contaminants such as DNA, endotoxins, and host cell proteins (HCP) that are small enough to pass through standard mechanical sieving filters.

• Scalable Process Development: The uPod design ensures linear scalability, allowing for a seamless transition of filtration parameters from R&D and laboratory settings to pilot and full-scale manufacturing Pod assemblies.

• Encapsulated Security: The fully enclosed polypropylene housing minimizes hold-up volume and eliminates the risk of bypass or external contamination, ensuring high product recovery and operator safety.

Product Specifications

• Catalog Number: MDE3023CL3

• Filtration Area: 23 cm2 (0.0023 m2)

• Media Type: DE30 (Diatomaceous Earth & Cellulose)

• Device Format: uPod (Process Development Scale)

• Housing Material: Glass-filled Polypropylene

• Max Operating Pressure: 2.1 bar (30 psid) at 40°C

• Connections: Standard Luer-lok compatible ports.

Key Benefits & Applications

• Primary Harvest Clarification: Ideal for the initial removal of cell mass from mammalian cell cultures (CHO), yeast, or bacterial lysates where high turbidity is present.

• Downstream Protection: Effectively reduces the particulate and impurity load to protect more sensitive downstream steps, such as sterile filtration or Protein A chromatography.

• Disposable Efficiency: As a single-use technology, it eliminates the need for cleaning validation and reduces setup times, facilitating faster throughput in multi-product facilities.

• Low Extractables: Manufactured to meet stringent biopharmaceutical standards for purity, ensuring minimal interference with sensitive analytical testing or final product quality.

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