Corning Erlenmeyer Flask 3L with Vent Cap Baffled Polycarbonate Case of 4 Flasks

The Corning 431253 Erlenmeyer Flask is a high-capacity 3 Liter culture vessel designed to support the scale-up of suspension cell lines, bacteria, and yeast. Precision-molded from virgin polycarbonate (PC), this flask offers the ideal combination of glass-like optical clarity for easy culture inspection and the high mechanical strength of plastic, making it shatterproof and safe for rigorous laboratory environments. Its 3L capacity serves as a critical intermediate step for researchers moving from small bench-scale flasks to larger 5L vessels or bioreactors.

A key performance feature of this specific model is its baffled bottom. The base of the flask contains molded-in indentations that act as agitators during orbital shaking. These baffles actively disrupt the laminar flow of the liquid, creating turbulence that significantly enhances the oxygen transfer rate (OTR) and prevents cells from clumping or settling. This increased aeration is essential for achieving higher cell densities and maximizing protein expression in aerobic cultures compared to standard flat-bottom designs.

The flask is fitted with a wide Vent Cap that incorporates a 0.2 µm hydrophobic membrane. This membrane facilitates the substantial gas exchange required by large-volume, high-density cultures while maintaining a sterile barrier against airborne contaminants and preventing liquid leakage. Delivered sterile (gamma irradiated) and individually packaged, the flask is ready for immediate use, eliminating the cleaning and autoclaving validation burdens associated with reusable glass Fernbach flasks.