Novasep Filter Manifold SIUS Low Volume Plate Insert

Novasep / Sartorius TFPLS-LVFL SIUS™ Low Volume Plate Insert

The Novasep TFPLS-LVFL is a precision-engineered manifold component designed for the SIUS™ Tangential Flow Filtration (TFF) platform. This Low Volume Plate Insert is specifically developed to optimize the fluid path within the TFF holder, significantly reducing the internal holdup (dead) volume of the system. By minimizing the volume of the manifold channels, this insert allows for higher concentration factors and ensures maximum recovery of high-value biological products, even when processing small starting volumes. Manufactured from high-durability, chemically resistant materials, the TFPLS-LVFL is an essential tool for process development and pilot-scale purification where sample conservation and yield are paramount.

Technical Performance and Design

• Minimized Holdup Volume: The internal flow channels are precision-machined to the smallest possible diameter consistent with efficient flux, allowing for the processing of low-volume batches (down to a few milliliters) without significant loss.

• Optimized Flow Dynamics: Engineered to maintain consistent pressure and sweep velocity across the TFF membrane surface, ensuring that the low-volume optimization does not compromise filtration efficiency or product stability.

• Seamless SIUS™ Integration: Designed for a perfect "drop-in" fit within the standard SIUS™ TFF manifold and plate-and-frame holders, requiring no specialized tools for installation or removal.

• High Purity & Compatibility: Constructed from materials that meet stringent biopharmaceutical requirements, offering broad chemical compatibility with common buffers, cleaning agents, and sanitization protocols (CIP).

Product Specifications

• Catalog Number: TFPLS-LVFL

• System Compatibility: Novasep / Sartorius SIUS™ TFF Systems

• Part Type: Low Volume Plate Insert / Manifold Plate

• Material: High-Performance Polymer / Stainless Steel (depending on specific revision)

• Function: Holdup volume reduction for small-scale concentration and diafiltration.

• Cleaning: Autoclavable and compatible with standard CIP (Clean-in-Place) procedures.

Key Benefits & Applications

• High-Value Protein Recovery: Ideal for researchers working with expensive monoclonal antibodies, recombinant proteins, or rare enzymes where every milliliter of product counts.

• Process Development: Allows for the determination of final concentration limits during R&D without requiring large quantities of starting material.

• Viral Vector Concentration: Used in gene therapy workflows (AAV/Lentivirus) to reach the extremely high concentrations required for downstream formulation.

• Enhanced Concentrating Power: By reducing the minimum loop volume of the TFF system, this insert enables researchers to push the concentration factor well beyond what is possible with standard manifold plates.

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