Avanti Heating Block Mini Extruder Holder

Avanti 610024 Mini-Extruder Heating Block / Holder

The Avanti 610024 is a vital accessory block designed to house the Avanti Mini-Extruder, providing both mechanical stability and precise thermal control during lipid extrusion. Manufactured from highly thermally conductive metal, this block is engineered to sit directly on a standard laboratory hot plate. It rapidly transfers heat to the central stainless-steel extruder hub and the opposing glass syringes, allowing researchers to maintain complex lipid suspensions at elevated temperatures. This is a mandatory requirement when formulating liposomes with synthetic phospholipids or sphingomyelins that possess a phase transition temperature (Tm) above room temperature. Furthermore, the block acts as a secure stabilizing stand, keeping the delicate syringe plungers perfectly aligned during the application of high manual pressure, thereby preventing catastrophic glass breakage.

Technical Performance and Design

• Precision Thermal Transfer: The conductive metal architecture efficiently draws heat from a hot plate and distributes it evenly across the fluidic path, preventing localized cold spots where lipids could rapidly crystallize.

• Secure Apparatus Holder: Features custom-machined channels that perfectly cradle the two 1000 µL (or 250 µL) glass syringes and the central extruder body, providing a rigid, unmoving foundation during forceful manual extrusion.

• Maintains Lipid Fluidity: Actively prevents high-Tm saturated lipids (such as DPPC or DSPC) from "crashing out" or turning into a rigid gel phase inside the syringes during the standard 11-pass LUVET protocol.

• Compact Hot Plate Footprint: The streamlined, low-profile design ensures it easily fits on any standard benchtop stirring hot plate while keeping the syringe plungers easily accessible to the researcher.

Product Specifications

• Catalog Number: 610024

• Compatible System: Avanti Mini-Extruder (610000 / 610020)

• Function: Temperature Control / Mechanical Holder

• Material: Thermally Conductive Metal

• Required Equipment: Standard Laboratory Hot Plate

Key Benefits & Applications

• High-Tm Lipid Extrusion: The absolute gold-standard accessory for formulating temperature-sensitive liposomes, targeted drug delivery vehicles, and mRNA-LNP complexes.

• Reduces Filter Fouling: Keeping the lipid suspension well above its phase transition temperature dramatically lowers the fluid viscosity, drastically reducing the required physical pushing force and preventing ruptured polycarbonate membranes.

• Enhanced Safety: Protects the user from directly handling hot stainless steel or applying excessive manual force to an unstable, unanchored fluidic setup.

• Rapid Prep Time: Quickly brings the syringe volumes up to the target formulation temperature, significantly reducing "down-time" between different lipid batches.

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