BIA Separations CIMmultus SO3 Monolithic Column 6 um Pore Size

BIA Separations 311.6157-6 CIMmultus SO3 Monolithic Column – 6 µm Pore, Strong Cation Exchange

The BIA Separations 311.6157-6 is a high-resolution monolithic column designed for the preparative and analytical purification of large biomolecules. Featuring the SO3 (Strong Cation Exchange) chemistry, this column utilizes a sulfur-based functional group to provide consistent negative charge across a wide pH range. The unique CIM (Convective Interaction Media) monolithic structure consists of a single piece of porous polymer with large, interconnected channels (6 µm pore size). This architecture enables convective mass transfer, allowing for exceptionally high flow rates without sacrificing binding capacity or resolution. The 311.6157-6 is specifically engineered for the efficient capture and purification of viruses, virus-like particles (VLPs), and large proteins, making it a critical tool for vaccine development and gene therapy manufacturing.

Technical Performance and Design

• Convective Mass Transfer: The monolithic design eliminates the diffusion limitations found in traditional bead-based resins, ensuring that separation performance remains constant regardless of the flow rate.

• Strong Cation Exchange (SO3) Chemistry: Provides high binding efficiency for positively charged biomolecules, maintaining a consistent charge density for reliable and reproducible chromatographic separations.

• Large 6 µm Pore Size: Specifically optimized for the purification of very large bioparticles (up to several hundred nanometers), ensuring low backpressure and preventing column clogging even with complex feedstocks.

• High-Flow Productivity: Enables rapid processing times and high throughput, which is essential for preserving the stability of labile biological products during purification.

Product Specifications

• Catalog Number: 311.6157-6

• Chemistry: SO3 (Strong Cation Exchange)

• Pore Size: 6 µm

• Ports: 10-32 UNF Coned Port

• Tubing Compatibility: 1/16 in. OD Tubing Connection

• Housing Material: High-performance plastic / Composite

• Flow Direction: Marked on column housing

Key Benefits & Applications

• Viral Vector Purification: Extensively used in the downstream processing of AAV and other viral vectors, where the large pores allow for high-capacity binding and gentle elution.

• Vaccine Manufacturing: The convective flow allows for the rapid processing of large volumes of cell culture supernatant, maximizing the recovery of active viral particles or VLPs.

• Scalability: The CIMmultus platform is designed for seamless scale-up, with identical geometry and flow dynamics from lab-scale units to industrial-sized production monoliths.

• Standard HPLC/FPLC Integration: The 10-32 UNF coned ports and 1/16" tubing compatibility allow for easy connection to any standard chromatography system (e.g., AKTA, Waters, or Agilent).

Expiration Date: March 2025.

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