Biotage Microplate Evolute ABN 96 Well 25 mg Each Well Sealed Plate

Biotage 600-0025-P01 EVOLUTE ABN 96-Well SPE Plate – 25 mg/well

The Biotage 600-0025-P01 is an EVOLUTE ABN Solid Phase Extraction (SPE) 96-well plate engineered for the simultaneous extraction of acidic, basic, and neutral analytes from complex biological matrices. Each well contains 25 mg of a proprietary, water-wettable polystyrene-divinylbenzene (PS-DVB) polymeric sorbent modified with hydroxyl groups. This carefully balanced hydrophilic and hydrophobic surface is designed to completely prevent the retention of large, endogenous macromolecules like proteins and phospholipids. By aggressively stripping away these matrix interferences, this fixed-well plate produces ultra-clean extracts that significantly reduce ion suppression and maximize signal-to-noise ratios during sensitive LC-MS/MS quantification workflows.

Technical Performance and Design

• Water-Wettable ABN Sorbent: The advanced Acid-Base-Neutral (ABN) polymer eliminates the risk of phase collapse if the sorbent bed accidentally runs dry during conditioning, providing exceptional recovery rates and robust analytical reproducibility.

• Ultra-Clean Extracts: The optimized pore structure is precisely engineered to exclude high-molecular-weight endogenous materials, directly preventing mass spectrometer source fouling and debilitating ion suppression.

• Fixed 96-Well Architecture: The standardized 96-well format seamlessly integrates with automated liquid handlers and positive pressure manifolds (such as the Biotage PRESSURE+ 96), enabling rapid, high-throughput parallel sample processing.

• Streamlined Methodology: The highly versatile chemistry allows researchers to utilize a single, generic "load-wash-elute" protocol for a massive variety of target analytes, drastically cutting down on tedious method development time.

Product Specifications

• Catalog Number: 600-0025-P01

• Product Line: EVOLUTE ABN

• Format: 96-Well Fixed Plate

• Sorbent Mass: 25 mg per well

• Sorbent Type: Wettable PS-DVB Polymer (Non-polar / Reverse Phase)

• Target Analytes: Acidic, Basic, and Neutral Compounds

Key Benefits & Applications

• Bioanalytical & Clinical Testing: The absolute gold standard for extracting a broad polarity range of pharmaceutical drugs, steroids, and biomarkers from viscous human plasma, serum, and urine.

• LC-MS/MS Optimization: Yields exceptionally clean extracts that can dramatically increase mass-spec signal intensity (often up to 4x higher) compared to traditional silica-based or competitive resin SPE products.

• Forensic Toxicology: Highly effective for broad-spectrum drugs of abuse screening where multiple classes of illicit substances must be extracted from a single bio-fluid sample simultaneously.

• Automation Ready: The rigid plate construction prevents vacuum leaks or cross-talk between wells, ensuring reliable flow rates when under positive pressure or vacuum on automated extraction platforms.

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