CDS 6015 Empore SPE Extraction Disk Microplate C18 96 Well Total of 2 Plates

CDS Empore™ C18-SD High-Performance 96-Well Solid Phase Extraction Plate – 1.2 mL Well Capacity, 10 mg Bed Weight, Octadecyl Functionalized Silica Membrane, Polypropylene, Non-Sterile (MPN: 6015 / 6015SD)

The CDS Analytical Empore™ 6015 (alternatively cataloged under legacy 3M matrices as 6015SD or 70-2007-3982-2) is a premium, chromatography-grade 96-well Solid Phase Extraction (SPE) disk plate engineered for high-throughput sample preparation, matrix cleanup, and analyte concentration prior to LC-MS/MS analytical workflows. Molded from solvent-inert polypropylene, this standard-profile plate features 96 individual wells with a 1.2 mL operational working capacity. Rather than traditional loose-packed particulate beds, each well incorporates the patented Empore particle-loaded membrane extraction disk featuring C18-SD (Octadecyl-bonded silica, standard density, 50 µm particle size, endcapped). This unique matrix embeds the sorbent beads tightly within an inert PTFE micro-web framework, ensuring a highly uniform, dense particle bed that eliminates channeling and void spaces. This allows for rapid parallel extraction of strongly non-polar analytes from complex biological fluids with minimal elution volumes, boosting analytical sensitivity while safeguarding columns from downstream particulate fouling.

Technical Performance and Membrane Engineering

• Patented Empore Micro-Web Membrane Technology: Sorbent particles are structurally locked within a fine polytetrafluoroethylene (PTFE) mesh framework. This eliminates the dynamic channeling, bed fluidization, and structural shifting common to loose-packed SPE alternatives, ensuring absolute flow uniformity across all 96 wells.

• Ultra-Low Elution Volume Headroom: The dense, thin membrane format delivers a high theoretical plate count with a small 10 mg sorbent bed mass. This allows targets to be eluted cleanly in as little as 100 µL to 150 µL of mobile phase, allowing for direct chromatographic injection and eliminating tedious solvent evaporation phases.

• Endcapped strongly Non-Polar C18-SD Chemistry: The octadecyl-functionalized silica matrix provides strongly non-polar, hydrophobic interaction properties. Comprehensive chemical endcapping minimizes secondary polar silanol interactions, yielding excellent peak shapes and symmetric separations for basic and neutral organic drugs.

• Particulate Fines Suppression: The integrated membrane design serves as a structural barrier that retains micro-particulates and fine silica dust. This ensures eluates are completely free of loose fines, preventing downstream LC injection loop blockage and column head fouling.

Product Specifications

• Catalog Number / MPN: 6015 (Cross-listed as 6015SD / 70-2007-3982-2 / 13-110-000)

• Manufacturer / Brand: CDS Analytical / Empore™ (Formerly manufactured by 3M Purification)

• Format Grid Layout: Standard 96-Well Plate Footprint (8 x 12 matrix meeting global ANSI/SLAS parameters)

• Volumetric Capacity: 1.2 mL standard well volume

• Sorbent Phase Chemistry: C18-SD (Octadecyl-Bonded Silica, Standard Density, Endcapped)

• Physical Sorbent Metrics: 10 mg bed weight mass per well / 40 to 60 µm average particle distribution

• Enclosure Material: Chemical-resistant, low-extractable virgin polypropylene

• Well Bottom Interface: Stepped collar nozzles designed to nest cleanly inside 96-well collection plates to block cross-contamination

• Standard Case Configuration: Case of 12 Extraction Plates total

Key Benefits and Applications

• Bioanalytical & Clinical Mass Spec Prep: The benchmark method foundation for high-throughput extraction of small-molecule therapeutics, drugs of abuse, steroid panels, and endogenous metabolites from complex serum, plasma, and whole blood matrices.

• Parallel High-Throughput Processing: Uniform flow kinetics allow a full 96-sample batch array to be fully processed, washed, and eluted under vacuum or positive pressure manifolds in under one hour, dramatically accelerating analytical throughput.

• Automated Liquid Handling Integration: The rigid standard plate footprint integrates smoothly with robotic liquid handling decks, automated vacuum manifolds (e.g., Empore Model 610), and automated injection stations.

• Streamlined Method Development: Small bed volumes require smaller sample portions, protecting limited clinical stocks while slashing total organic solvent consumption and associated laboratory hazardous waste disposal overhead.

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