Corning Culture Plates 384 Well Low Volume Round Bottom Sealed Case of 50 Plates

Corning 384-Well Low Volume Solid White Round Bottom NBS Microplates, Non-Sterile (4513) – Case of 50

The Corning 384-Well Low Volume White Microplates with Nonbinding Surface (4513) are specialized, high-density assay plates engineered for miniaturized homogeneous assays, fluorescence/luminescence screening, and low-concentration target binding studies. Constructed from solid white polystyrene, these microplates feature a light cone-shaped conical well geometry with round bottoms, which minimizes trapped air bubbles, lowers working volume requirements, and enhances the overall Z-factor for high-throughput screening (HTS). Treated with Corning’s proprietary Nonbinding Surface (NBS) technology, the nonionic hydrophilic surface prevents non-specific protein and nucleic acid adsorption to well walls. Supplied as a case of 50 non-sterile plates (packaged as 5 inner bags of 10 plates each, without lids), this consumable line delivers high signal-to-noise performance for automated biochemical assays.

Technical Performance & Key Attributes

• Proprietary Nonbinding Surface (NBS) Treatment: Creates a nonionic hydrophilic surface (polyethylene oxide-like) that reduces molecular interactions and prevents non-specific binding of proteins and DNA/RNA at low concentrations.
• Miniaturized Low Volume Geometry: Conical light-cone well design with a round bottom allows a recommended working volume of just 5 µL to 40 µL, conserving costly reagents while maximizing assay signal efficiency.
• Solid White Opaque Walls: Reflects emitted light signals to boost luminescent intensity while eliminating well-to-well crosstalk and background autofluorescence.
• Robotic Pipetting Efficiency: Features a square well top profile that increases the target opening area for automated liquid handling tips and multi-channel dispensers.

Product Specifications

• Catalog Number / MPN: 4513 (Suggested replacement for Corning 3673)
• Primary Manufacturer: Corning Life Sciences
• Plate Format: 384-Well Low Volume Microplate (16 x 24 Array)
• Well Shape & Bottom Profile: Square Top with Round / Conical Bottom (U-Bottom)
• Total Well Volume: 50 µL per well
• Recommended Working Volume: 5 µL to 40 µL per well
• Material Composition: Optical-Grade Solid White Polystyrene (PS)
• Surface Treatment Status: Nonbinding Surface (NBS) Treatment
• Sterility Status: Non-Sterile
• Lid Status: Supplied without lids
• Packaging Configuration: Case of 50 microplates (5 inner bags x 10 plates per bag)

Key Benefits & Applications

• High-Throughput Screening (HTS): Optimized for miniaturized fluorometric, luminescent, and homogeneous proximity assays (e.g., LANCE, AlphaScreen, and TR-FRET).
• Low Concentration Target Protection: NBS treatment prevents target biomolecules from sticking to plastic walls, enhancing signal-to-noise ratios in delicate binding kinetics.
• Reagent Savings: Low working volume range (5–40 µL) dramatically reduces enzyme, fluorophore, and substrate consumption during large-scale library screens.
• Automated Handling Fit: Conforms to standard ANSI/SLAS microplate dimensions for seamless integration into robotic grippers, plate washers, and readers.

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