Corning Centrifuge Tube 500 ml Conical Bottom Polypropylene Case of 36 Tubes

Corning® 500 mL Polypropylene Conical Bottom Centrifuge Tubes, Plug Seal Caps (431123) – Case of 36

The Corning® 431123 is a premium, large-volume fluid processing consumable engineered for high-capacity sample centrifugation, large-scale cell harvesting, bioprocessing pelleting, and chemical separation loops. Precision-molded from translucent, high-purity virgin polypropylene, these 500 mL conical tubes exhibit high mechanical and chemical resistance across a broad range of biological acids, bases, and organic reagents. The tube integrates a heavy-duty **polyethylene plug seal cap** that establishes a gas- and liquid-tight mechanical compression seal, completely suppressing fluid weeping or sample aerosolization under maximum structural load. Supplied as a commercial case of 36 tubes (organized in 6 convenient, sterile bags of 6 tubes each), this large-scale single-use configuration is standard hardware for pilot plants, upstream cell culture facilities, and vaccine development cleanrooms.

Technical Performance & Material Architecture

• High-Volume Mechanical Rating: Advanced injection molding technology enables the wide conical polypropylene base to withstand physical acceleration stresses up to 6,000 x g (RCF) when paired with appropriate support cushions inside matching large-capacity swinging-bucket or fixed-angle rotors.
• Deep-Molded Plug Seal Cap Geometry: Outfitted with a signature orange high-density polyethylene (HDPE) screw cap featuring an internal cylindrical plug seal interface. This plug seats deep inside the wide mouth neck, providing a reliable dual-surface boundary that prevents leakage during dynamic agitation or cold room chemical extraction runs.
• Molded Volumetric Graduation Scale: Features clear, molded-in graduations along the side of the translucent tube body, running from 50 mL up to 450 mL in precise increments. This durable design ensures continuous volumetric tracking that cannot peel or wash off when exposed to alcohol wipes or ambient laboratory condensed moisture.
• Low-Density Aseptic Bagged Packaging: Packaged in durable, heavy-gauge polymer sleeves containing 6 tubes each (6 bags per case). This localized inner packaging allows facilities to introduce a minimal number of sterile tubes to a hood or clean bench line while keeping the remaining master inventory protected from environmental dust.

Product Specifications

• Catalog Number / MPN: 431123
• Primary Manufacturer: Corning Life Sciences
• Nominal Volumetric Capacity: 500 mL
• Tube Base Geometry: Wide Conical-Bottom (Requires specialized 500 mL rotor adapters or matching support cushions for safe spinning)
• Closure Mechanism: Threaded Wide-Mouth Screw Cap with integrated Plug Seal architecture
• Material Chemistry: Premium Virgin Polypropylene (PP) Tube Body | High-Density Polyethylene (HDPE) Cap | 100% Latex-Free
• Color Identification Matrix: Signature Corning Orange Cap Identification
• Maximum Relative Centrifugal Force (RCF): Certified up to 6,000 x g when fully supported
• Sterility & Purity Standards: Gamma radiation-sterilized; Certified Non-Pyrogenic and low extractable
• Packaging Configuration: Case of 36 Tubes (Divided into 6 sterile bags of 6 tubes each, packaged inside a track-coded master shipping carton)

Key Benefits & Applications

• Upstream Biomanufacturing and Pelleting: The premier choice for harvesting large volumes of bacterial, yeast, or mammalian suspension cell biomass directly from benchtop bioreactors or shaker flasks.
• Large-Scale Reagent Storage and Separation: Serves as an excellent, chemically inert container for processing large volumes of culture supernatants, chemical precipitates, or bulk washing buffers.
• Concentration and Clarification Loops: Ideal for scaling up initial sample processing stages prior to downstream clarification steps with analytical vacuum devices like **Thermo Scientific Nalgene Rapid-Flow Filter Units**.
• **cGMP Facility Lot Serialization:** Every manufacturing master carton is marked with a unique lot code, ensuring complete, audit-ready product tracking across industrial medical and pharmaceutical laboratory networks.

Corning® is a registered commercial trademark of Corning, Inc. Catalog number 431123 specifies the 500 mL polypropylene conical centrifuge tube with an orange plug seal cap. For workflows that do not possess swinging-bucket rotors with custom 500 mL cavities, companion **Corning 15 mL Conical Tubes (SKU 430766)** or larger flat-bottom storage configurations should be utilized depending on the rotor specifications of the facility.