Corning Culture Flask with Phenolic Cap 175 cm2 Angled Neck Case of 50 Flasks

Corning 431085 Cell Culture Flask – 175 cm², Angled Neck, Polystyrene

The Corning 431085 is a 175 cm² tissue culture treated flask engineered for the large-scale cultivation and expansion of anchorage-dependent mammalian cell lines. Molded from optically clear virgin polystyrene, the flask features a standardized physical-chemical surface treatment that optimizes the hydrophilic properties of the polymer to promote uniform cellular attachment and spreading. This specific model is equipped with an angled neck design to facilitate easier pipette and cell scraper access, and a solid phenolic screw cap, which provides a heavy-duty, airtight seal ideal for closed-system incubation or liquid transport applications.

Technical Performance and Design

• Tissue Culture Surface Treatment: The polystyrene undergoes a permanent vacuum-gas plasma treatment, introducing negatively charged functional groups onto the polymer to maximize cell attachment and monolayer consistency.

• Angled Neck Geometry: The precise tilt of the entry neck allows standard serological pipettes or cell scrapers to easily reach the interior corners of the 175 cm² growth area, reducing dead spots and improving total cell harvest yields.

• Phenolic Style Cap: Fabricated from high-density, autoclavable phenolic resin with a rubber liner. This solid closure mechanism forms a secure, leak-proof barrier, preventing fluid leakage and atmospheric exchange unless manually loosened to a "thread-back" position.

• Anti-Tip Base Profile: The flask is engineered with a wide base stability profile and specific molded ridges that allow for secure stacking in incubators, maximizing functional space while maintaining uniform airflow around the vessels.

Product Specifications

• Catalog Number: 431085

• Growth Area: 175 cm²

• Neck Style: Angled

• Material: Clear Polystyrene (PS)

• Cap Material: Phenolic Resin (Solid, Non-Vented)

• Sterility: Sterile (Gamma Irradiated), Non-Pyrogenic

• Packaging: Case of 50 Flasks (5 Flasks per Pack)

Key Benefits & Applications

• Adherent Cell Expansion: The standard scale-up vessel for growing larger biomass volumes of anchorage-dependent cells prior to harvesting for downstream bioassays or seeding into bioreactors.

• Closed System Cultivation: The solid phenolic cap is specifically required for applications requiring strict isolation from external atmospheres, such as industrial vaccine production or anaerobic cell incubation.

• High Volumetric Capacity: The structural volume easily accommodates up to 50 mL of media safely, allowing for longer intervals between fluid changes during slow-growing primary cell cultures.

• Distortion-Free Microscopy: The ultra-flat growth surface and glass-like optical clarity allow for clear, sharp phase-contrast imaging of cell morphology directly through the bottom of the flask.

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