Corning Erlenmeyer Flask 500 ml with Vent Cap PC Case of 25 Flasks

Corning 431145 Erlenmeyer Flask – 500 mL, Plain Bottom, Vent Cap

The Corning 431145 is a 500 mL high-performance Erlenmeyer flask engineered for scale-up cell culture and medium-volume laboratory applications. This model features a plain (flat) bottom design, which provides optimal fluid dynamics for sensitive suspension cultures that require lower shear forces. Manufactured from optically clear, shatterproof polycarbonate, this flask offers a safer and more durable alternative to glass for use in orbital shakers. The wide-mouth design facilitates easy filling and pipetting, while the integrated 0.2 micron hydrophobic vent cap ensures continuous, sterile gas exchange while maintaining a secure seal against contaminants and leakage.

Technical Performance and Design

• Plain (Flat) Bottom Design: Provides a smooth surface for uniform mixing at lower speeds, making it ideal for shear-sensitive mammalian cell lines and general media storage.

• 0.2 µm Hydrophobic Vent Cap: The breathable polypropylene cap contains a high-efficiency membrane that allows for optimal CO2 and O2 exchange while preventing microbial ingress and liquid leakage.

• High-Clarity Polycarbonate: Provides the optical transparency of glass with superior mechanical strength, allowing for easy visual monitoring of culture density and media color changes.

• Sterile & Non-Pyrogenic: Supplied gamma-irradiated (SAL 10⁻⁶) and certified non-pyrogenic, ensuring the flask is ready for immediate use in sensitive bioprocessing workflows.

Product Specifications

• Catalog Number: 431145

• Capacity: 500 mL

• Bottom Style: Plain / Flat Bottom

• Neck Style: Wide Mouth

• Material: Polycarbonate (USP Class VI)

• Cap Type: Vent Cap (0.2 µm Membrane)

• Sterility: Sterile (Gamma Irradiated)

Key Benefits & Applications

• Mammalian Cell Culture: The industry-standard vessel for the expansion of CHO, HEK293, and other suspension cell lines where steady, controlled aeration is required.

• Media Preparation & Storage: The robust construction and breathable cap make it excellent for preparing, transporting, and storing sterile culture media and buffers.

• Shatterproof Safety: Eliminates the safety hazards associated with glass breakage in high-traffic laboratories or within mechanical shaking incubators.

• Single-Use Efficiency: Eliminates the labor-intensive cleaning and sterilization validation associated with reusable glassware, reducing the risk of batch-to-batch carryover.

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