Corning Erlenmeyer Flask 5L with Vent Cap Baffled Polycarbonate Case of 4 Flasks

Corning 5 L Baffled Polycarbonate Erlenmeyer Flask with Vent Cap (431684)

The Corning 431684 is a high-capacity, 5-liter Erlenmeyer flask engineered for large-scale suspension cell culture and aerobic fermentation. Manufactured from optically clear, medical-grade polycarbonate, this flask features a triple-baffled bottom designed to significantly increase oxygen transfer by disrupting laminar flow and increasing surface area during orbital shaking. The unit is equipped with a large-diameter 70 mm vent cap featuring a 0.2 µm hydrophobic membrane, which facilitates continuous, high-flow sterile gas exchange while preventing liquid wetting and environmental contamination. Shatter-proof and delivered gamma-sterilized, the 431684 provides a safer, more efficient, and scalable alternative to glass Fernbach flasks, making it an essential tool for high-density protein expression and pilot-scale bioprocessing.

Technical Performance and Design

• Maximum Aeration Baffled Design: Three deep-molded baffles at the base prevent the formation of a central vortex during shaking, ensuring vigorous mixing and superior dissolved oxygen levels for oxygen-demanding microbial and mammalian cultures.

• High-Efficiency Venting: The 70 mm wide-mouth cap integrates a 0.2 µm microporous PTFE membrane, allowing for maximum CO2 and O2 exchange while maintaining a completely closed, sterile system.

• Shatter-Proof Polycarbonate: Constructed from high-impact, medical-grade resin that offers the optical transparency of glass with the safety of plastic, eliminating the risk of hazardous glass breakage during high-speed shaker operation.

• Scale-Up Optimization: The 5-liter volume allows researchers to bridge the gap between benchtop flasks and bioreactors, providing a consistent environment for transitioning culture volumes.

Product Specifications

• Catalog Number: 431684

• Capacity: 5 Liters (5000 ml)

• Base Style: Baffled Bottom

• Cap Style: 70 mm Vent Cap (Orange)

• Material: Polycarbonate (Flask); High-Density Polyethylene (Cap)

• Sterility: Sterile (Gamma Irradiated to SAL 10^-6)

• Purity: Certified Non-Pyrogenic, Non-Cytotoxic, and DNase/RNase Free.

• Graduations: Molded-in for quick volume estimation.

Key Benefits & Applications

• High-Yield Protein Expression: Specifically designed for culturing E. coli and yeast strains that require maximum aeration to achieve high biomass and recombinant protein levels.

• Vaccine & Biologic Production: The single-use format eliminates cleaning validation and cross-contamination risks in GMP-compliant research and production workflows.

• Large-Volume Media Preparation: The robust design and wide mouth make it an excellent vessel for the sterile preparation and short-term storage of large-batch culture media.

• Orbital Shaker Compatibility: Optimized for use in large-capacity floor shakers; the 5L volume maximizes the available footprint for high-output culture labs.

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