Corning Microplate Lids for 96 Well Plates Low Evaporation with Notch 100 Lids

Corning Costar 96-Well Microplate Low-Evaporation Lids – Crystal Clear Polystyrene, Corner Notch Alignment, Condensation Rings, Sterile, Non-Pyrogenic (MPN: 3931)

The Corning Life Sciences 3931 (also cataloged as 3931-CS / CLS3931) is a premium, cell-culture-grade microplate lid precision-engineered to provide robust environmental containment, absolute optical clarity, and advanced evaporation control for high-throughput screening and delicate cellular assays. Injection-molded from ultra-pure, crystal-clear virgin polystyrene, this rigid lid features a universal rectangular footprint designed to fit standard 96-well flat, round, or V-bottom microplates and assay blocks. The lid incorporates individual, precision-molded vertical condensation rings that align perfectly over each well to intercept moisture tracking and maintain a uniform vertical headspace environment. Outfitted with a specialized directional corner notch to prevent orientation errors, these sterile lids are ideal for cell culture workflows, minimizing edge-effect evaporation over multi-day incubation cycles.

Technical Performance and Engineering

• Advanced Low-Evaporation Matrix: Designed with individual micro-condensation rings built into the ceiling profile. These rings guide evaporating moisture back down into the origin wells, preventing erratic volume drops and suppressing the devastating "edge-effect" during long incubations.

• Unidirectional Corner Notch Layout: The lower outer corner of the lid is engineered with a strict mechanical structural notch. This configuration fits perfectly against corresponding notched plate shoulders, ensuring the lid can only be seated in one orientation to remove cross-well mixing mistakes.

• Validated Medical-Grade Purity: Sterilized via validated gamma irradiation protocols to secure an aseptic state. Every factory lot is independently certified non-pyrogenic (endotoxin level less than 0.1 EU/mL) and non-cytotoxic to defend primary cells and stem line expansions.

• Optically Clear Assay Scanning: The high-transmission virgin polystyrene matrix allows for uninterrupted visual inspection under light microscopes and supports standard vertical colorimetric or fluorescence plate reader scans without removing the protective shield.

Product Specifications

• Catalog Number / MPN: 3931 (Cross-listed as CLS3931 / 3931-CS)

• Manufacturer / Brand: Corning Life Sciences / Costar®

• Format Microplate Suitability: Optimized for all standard 96-well microplates, high-binding ELISA plates, and tissue culture blocks (ANSI/SLAS footprint compliant)

• Material Composition: Ultra-Clear Rigid Virgin Polystyrene (PS)

• Specialized Features: Low Evaporation Condensation Rings / Directional Corner Orientation Notch

• Sterility Metric / Packaging: Gamma Irradiated Sterile (Individually blister-packed or sleeved in cleanroom bundles)

• Standard Case Configuration: Case of 100 Lids total (Divided into 4 convenient inner packages containing 25 lids per sterile sleeve)

Key Benefits and Applications

• Cell Culture and Hybridoma Seeding: The gold standard protective barrier for multi-day cell growth, tissue culture expansion loops, and transfection assays carried out inside humidified carbon dioxide incubators.

• High-Throughput Automation Compatibility: Rigid external tolerances and low-profile vertical stacking shoulders allow automatic plate handler grippers, stacker cassettes, and barcode scanners to load and clear the lids cleanly without stalling.

• Elisa Reagent Evaporation Defense: Prevents volume loss and baseline concentration drift during high-temperature plate incubations or prolonged antibody coating stages, maintaining signal linearity across assay rows.

• Contamination-Protected Airflow: Tightly calculated vertical skirt perimeters shield well grids from falling particulates and ambient cross-draft contamination while allowing smooth gas exchange loops required for cellular respiration.

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