Corning Microplate with Lid 384 Well 90 ul PS Round Bottom 5 Plates

Corning 4516 Microplate with Lid – 384-Well, 90 µL, Round Bottom, TC-Treated

The Corning 4516 is a premium 384-well microplate engineered for high-throughput cell-based assays and screening applications. Manufactured from medical-grade, high-clarity polystyrene, the plate surface is vacuum-gas plasma treated (Tissue Culture Treated) to enhance hydrophilicity and promote consistent cell attachment and growth across all 384 wells. The specialized round-bottom geometry is designed to facilitate efficient mixing and minimize dead volume during automated aspiration. With a 90 µL total well volume, the 4516 allows for significant reagent savings while maintaining a high signal-to-noise ratio for various detection methods. Each plate is supplied sterile and individually wrapped with a breathable lid featuring a condensation ring to ensure a contamination-free environment and uniform gas exchange during long-term incubation.

Technical Performance and Design

• Tissue Culture (TC) Treated Surface: The surface chemistry is optimized for the uniform attachment and expansion of anchorage-dependent cell lines, ensuring consistent data across the entire high-density grid.

• Round-Bottom Well Geometry: Specifically designed for ease of mixing and total sample recovery, making it the ideal choice for assays involving bead-based separations or resuspension protocols.

• High-Density SBS Footprint: Fully compliant with industry standards, ensuring seamless compatibility with robotic plate handlers, automated liquid workstations (such as the Echo or Mosquito), and high-content imaging systems.

• Optically Clear Construction: The premium polystyrene allows for excellent light transmission, making the 4516 suitable for colorimetric assays and microscopic observation.

Product Specifications

• Catalog Number: 4516

• Well Count: 384 Wells

• Total Volume: 90 µL per well

• Material: High-Clarity Polystyrene

• Surface Treatment: Tissue Culture (TC) Treated

• Sterility: Sterile (Individually Wrapped with Lid)

Key Benefits & Applications

• High-Throughput Screening (HTS): The 384-well format allows for a four-fold increase in data points per plate compared to standard 96-well formats, drastically reducing plate-handling time and reagent costs.

• Cell-Based Assays: Ideal for cytotoxicity, proliferation, and gene expression studies where miniaturization is required without sacrificing cell health or data quality.

• Sample Dilution & Collection: The round-bottom design ensures that small volumes of concentrated stock solutions can be effectively diluted and retrieved by automated systems.

• Reproducible Incubation: The included lid and raised well rims are engineered to minimize the "edge effect," ensuring that peripheral wells maintain the same evaporation rate as interior wells.

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