Culture Plate with Lid 24 Well PS 9 Packs of 5 Plates Each - Total of 45 Plates

Corning 356414 BioCoat™ 24-Well Microplate (Collagen I Coated, with Lid)

The Corning 356414 is a high-performance 24-well microplate engineered for the advanced culture of primary cells and sensitive cell lines. Each well is precision-coated with a uniform layer of Fibrillar Collagen I, providing a biological substrate that mimics the natural extracellular matrix (ECM). This coating is specifically designed to enhance cell attachment, proliferation, and the expression of cell-specific morphologies in anchorage-dependent cultures. Manufactured from high-clarity medical-grade polystyrene, these plates ensure optimal microscopic visualization. Provided sterile and ready-to-use with an included lid, the 356414 is the industry standard for researchers performing drug metabolism studies, neurite outgrowth assays, and primary hepatocyte cultures.

Technical Performance and Design

• BioCoat™ Collagen I Surface: The fibrillar coating provides a more physiologically relevant environment than standard synthetic surfaces, significantly improving the success rate of primary cell attachment and long-term viability.

• Validated Lot-to-Lot Consistency: Every lot is rigorously tested for its ability to promote cell attachment and growth, ensuring reproducible experimental results across different laboratory runs.

• Optimized 24-Well Geometry: Features a flat-bottom design with a 1.9 cm² growth area per well, offering the perfect balance between sample volume and experimental throughput.

• Low-Evaporation Lid: The included lid features a specialized design to minimize evaporative loss and maintain stable media concentrations, while allowing for sterile gas exchange in the incubator.

Product Specifications

• Catalog Number: 356414

• Format: 24-Well Plate with Lid

• Surface Treatment: Collagen I (Fibrillar)

• Growth Area: 1.9 cm² per well

• Material: Clear Polystyrene (PS)

• Sterility: Sterile (Gamma Irradiated); Non-pyrogenic

• Storage Requirements: Room Temperature (2°C to 30°C)

• Packaging: 5 Plates per Pack / 5 Packs per Case

Key Benefits & Applications

• Primary Cell Culture: Specifically recommended for the successful cultivation of primary hepatocytes, fibroblasts, and epithelial cells that require ECM components for proper differentiation.

• Neurite Outgrowth Assays: The Collagen I substrate provides the necessary structural cues for the attachment and extension of neurites in primary neuronal cultures.

• Transfected Cell Lines: Ideal for maintaining "difficult-to-attach" transfected cell lines, preventing cell loss during rigorous washing steps in ELISA or immunofluorescence protocols.

• Toxicology & Drug Screening: Provides a highly stable and reproducible platform for metabolic studies where consistent cell density and attachment are critical for data accuracy.

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