Cytiva GE Bottom Filter Unit FineLINE Pilot 35 Column 2 um

Cytiva FineLINE Pilot 35 Bottom Filter Unit – 2 µm, Polypropylene (18110211)

The Cytiva 18110211 is a precision-engineered bottom filter unit specifically designed for use with FineLINE™ Pilot 35 chromatography columns. Featuring a 2 µm pore size, this polypropylene mesh filter serves as the primary barrier to retain chromatography resins within the column while ensuring uniform flow distribution of the mobile phase. Constructed from high-quality, biocompatible polypropylene, the filter offers excellent chemical resistance and mechanical stability required for pilot-scale downstream processing. As a genuine Cytiva replacement part, it ensures a perfect fit and maintains the high-pressure integrity and peak symmetry standards expected in regulated biopharmaceutical manufacturing environments.

Technical Performance and Design

• 2 µm Precision Filtration: The fine mesh size is optimized to retain small-diameter chromatography beads, preventing media leakage into the downstream flow path while maintaining low backpressure.

• Polypropylene Construction: Offers broad chemical compatibility with common chromatography buffers, cleaning-in-place (CIP) solutions (such as 1M NaOH), and organic solvents used in purification.

• Optimized Flow Distribution: Engineered to work with the FineLINE column's internal geometry to promote even flow across the entire cross-section of the bed, reducing "channeling" and improving HETP (Height Equivalent to a Theoretical Plate).

• Biocompatible & Regulatory Compliant: Manufactured from USP Class VI materials, ensuring that no leachable or extractable substances interfere with the purity of the final biological product.

Product Specifications

• Catalog Number: 18-1102-11

• Pore Size: 2 µm

• Compatible System: Cytiva FineLINE Pilot 35 Column

• Material: Polypropylene (PP)

• Position: Bottom Filter Unit

• Chemical Stability: Stable in pH 2-14; resistant to common alcohols and salt buffers.

Key Benefits & Applications

• Downstream Processing (DSP): A critical component in the purification of proteins, monoclonal antibodies, and vaccines at the pilot-plant scale.

• Process Validation: Using genuine Cytiva parts simplifies the validation process for cGMP manufacturing, ensuring the column performs exactly to the manufacturer's validated specifications.

• Easy Maintenance: Designed for straightforward replacement during routine column maintenance or resin changeovers, minimizing downtime in production schedules.

• Uniform Bed Support: Provides the structural integrity needed to support the packed bed under the high-compression forces typical of FineLINE hydraulic packing methods.

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