Cytiva GE Hollow Fiber Filter Tangential Flow Cartridge 0.1um

Cytiva 56-4102-70 CFP-1-E-6A Hollow Fiber Cartridge – 0.1 µm, 1.0 mm Lumen

The Cytiva 56-4102-70 (model CFP-1-E-6A) is an advanced Tangential Flow Filtration (TFF) hollow fiber cartridge designed for critical microfiltration operations in biopharmaceutical manufacturing. Unlike standard dead-end filters, this cartridge utilizes a cross-flow fluid path that continuously sweeps across the membrane surface. This dynamic action prevents the rapid buildup of a polarization layer, significantly reducing fouling and extending the operational life of the filter during high-volume processing. Equipped with a precise 0.1 µm pore size and a 1.0 mm lumen, the CFP-1-E-6A provides a gentle, low-shear environment perfect for processing dense, high-solids cell suspensions. With 0.28 m² of active surface area housed within a 60 cm path length, this module delivers highly accurate, scalable performance data that translates seamlessly to commercial-scale production.

Technical Performance and Design

• Tangential Flow Dynamics: The continuous sweep of the feed stream across the hollow fibers actively mitigates membrane fouling, allowing for much higher volumetric throughput and longer continuous run times than standard normal-flow filters.

• 0.1 µm Microfiltration Membrane: Provides a precise and absolute barrier for large particulates and whole cells, making it the industry standard for upstream clarification, yeast removal, or large-virus concentration.

• 1.0 mm Lumen Diameter: The 1.0 mm internal diameter of the hollow fibers ensures that highly concentrated biomass, cell lysates, or viscous broths can be circulated without generating excessive shear stress or prematurely plugging the fluid path.

• Pilot-Scale Optimization: The 60 cm path length is strategically designed to match the hydrodynamics of larger production-scale modules, ensuring reliable linear scale-up for process engineers.

Product Specifications

• Catalog Number: 56-4102-70 (Model: CFP-1-E-6A)

• Filtration Type: Tangential Flow Filtration (TFF) / Microfiltration

• Pore Size: 0.1 µm

• Fiber Inner Diameter (Lumen): 1.0 mm

• Path Length: 60 cm

• Membrane Area: 0.28 m² (2,800 cm²)

Key Benefits & Applications

• Gentle Cell Harvesting: The open lumen and low-shear fluid dynamics make it the gold standard for concentrating fragile mammalian cells (like CHO or HEK293) while maintaining extremely high cell viability.

• Lysate Clarification: Acts as a highly efficient primary clarification step to remove bulk cellular debris before sending the targeted supernatant to sensitive downstream chromatography columns.

• Wash and Diafiltration: Excellent for continuous buffer exchange or washing steps where target proteins need to be rapidly separated from larger aggregates and biological mass.

• Reusable & Cleanable: Designed to withstand rigorous Clean-In-Place (CIP) protocols—including prolonged exposure to sodium hydroxide (NaOH)—allowing the cartridge to be safely regenerated and repeatedly deployed.

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