Cytiva GE Hollow Fiber Filter Tangential Flow Cartridge 0.1um

Cytiva 56-4101-80 Hollow Fiber TFF Cartridge (0.1 µm, CFP-1-E-4MA)

The Cytiva 56-4101-80 (Model CFP-1-E-4MA) is a high-performance Tangential Flow Filtration (TFF) hollow fiber cartridge engineered for the clarification and concentration of biological suspensions. Featuring a 0.1 µm microfiltration membrane, this cartridge is constructed with Low Adsorption Polyethersulfone (PES), designed to provide high permeate flux while minimizing non-specific binding of proteins and other biomolecules. The "Size 4" housing and 1.0 mm fiber lumen diameter make it ideal for pilot-scale processing and small-batch production, providing the robust physical integrity required for repeated CIP (Clean-in-Place) and sterilization cycles.

Technical Performance and Design

• Microza Low Adsorption PES: The proprietary membrane chemistry offers a high degree of hydrophilicity, significantly reducing membrane fouling and ensuring stable flux rates during extended clarification runs.

• 1.0 mm Fiber Lumen: The larger 1.0 mm internal diameter is optimized for handling moderately viscous fluids and high-density cell suspensions, reducing the risk of fiber clogging compared to narrower lumen alternatives.

• High Surface Area Efficiency: The "4MA" configuration provides a balanced membrane area (approx. 420 cm²) suitable for QuixStand and Midgee-scale systems, allowing for seamless linear scale-up to larger production modules.

• Rugged Polysulfone Housing: The cartridge is encased in a durable polysulfone shell with standard 1/2-inch sanitary fittings, ensuring a secure, leak-proof connection to process piping and automation platforms.

Product Specifications

• Catalog Number: 56-4101-80 (CFP-1-E-4MA)

• Pore Size: 0.1 µm (Microfiltration)

• Membrane Material: Low Adsorption Polyethersulfone (PES)

• Lumen ID: 1.0 mm

• Cartridge Size: Size 4 (Approx. 30 cm length)

• Connections: 1/2-inch Sanitary Flange (TC) Inlet/Outlet and Permeate

• Sterilization: Autoclavable and compatible with Sodium Hydroxide (NaOH) sanitation.

Key Benefits & Applications

• Cell Harvesting & Clarification: The 0.1 µm pore size is specifically designed for the removal of whole cells and large cellular debris from mammalian, bacterial, or yeast fermentation broths.

• Viral Vector Concentration: Effectively used in the purification of large viral particles (such as Lentivirus or Adenovirus) where high recovery and low shear stress are paramount.

• Sterile Filtration Pre-step: Acts as an ideal pre-filter to 0.22 µm sterile membranes, removing bulk contaminants and extending the life of downstream pleated cartridges.

• Low Shear Processing: The hollow fiber geometry provides a gentle flow path with uniform shear, protecting shear-sensitive proteins and cells from degradation during the concentration process.

All product names, logos, and brands are property of their respective owners. Microza is a trademark of Asahi Kasei Medical Co., Ltd.