Cytiva Hollow Fiber Filter Cartridge 0.1 um 850 cm2

Cytiva RTPCFP-1-E-4X2MS Hollow Fiber Filter – 0.1 µm, 850 cm², Ready-to-Process

The Cytiva RTPCFP-1-E-4X2MS is a premium, single-use hollow fiber cartridge engineered for high-efficiency cross-flow filtration in biopharmaceutical development. Featuring a 0.1 µm pore size microfiltration membrane, this cartridge is optimized for the clarification of cell lysates, harvesting of mammalian or bacterial cells, and sterile filtration of complex biological fluids. As part of the Ready-to-Process (RTP) series, the unit is supplied pre-sterilized via gamma irradiation, eliminating the need for time-consuming cleaning validation and autoclaving. The 850 cm² effective filtration area and robust polyethersulfone (PES) membrane chemistry provide high flux rates and exceptionally low protein binding, ensuring maximum recovery of high-value proteins and viral vectors.

Technical Performance and Design

• Gamma-Sterilized (RTP): Delivered pre-sterilized and ready for immediate integration into aseptic closed-loop systems, significantly reducing setup time and the risk of batch contamination.

• 0.1 µm Polyethersulfone (PES) Membrane: Features a highly asymmetric pore structure that provides superior retention of fine particulates and microorganisms while maintaining high flow velocities.

• Low Non-Specific Binding: The modified PES membrane is designed to minimize the adsorption of proteins and nucleic acids, ensuring the integrity and yield of the final product.

• Hollow Fiber Geometry: The open-channel design is exceptionally tolerant of high-solids loading and turbid feedstreams, making it less prone to fouling than traditional flat-sheet TFF cassettes.

Product Specifications

• Catalog Number: RTPCFP-1-E-4X2MS

• Pore Size: 0.1 µm

• Surface Area: 850 cm² (0.085 m²)

• Fiber ID: 1.0 mm (optimized for medium-viscosity feeds)

• Membrane Material: Low-protein binding Polyethersulfone (PES)

• Housing Material: Polysulfone

• Sterility: Sterile (Gamma Irradiated)

Key Benefits & Applications

• Cell Harvest & Clarification: The ideal choice for the primary recovery of cells and the removal of cell debris from fermentation broths in both upstream and downstream processing.

• Viral Vector Purification: Extensively used in the production of AAV and Lentivirus, where gentle processing and high surface area are required to maintain viral titer and purity.

• Scalable Performance: The 850 cm² format provides a perfect scale-down model for larger production-scale hollow fiber systems, allowing for predictable process development.

• Disposable Efficiency: As a single-use cartridge, it supports the rapid turnaround of multi-product facilities by eliminating the resource-intensive requirements of CIP (Clean-in-Place) and SIP (Steam-in-Place).

Expiration Date: 2020-10

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