Millipore Capsule Filter OptiScale 47 Sealed Pack 3 Filters

Millipore SN50A47HH3 OptiScale 47 Polygard-CN Filter (5 µm)

The Millipore SN50A47HH3 is a precision-engineered OptiScale 47 screening device designed for process development, filterability studies, and scale-up optimization. Featuring a 47 mm disc of 5 µm Polygard-CN polypropylene depth media, this unit is specifically intended to provide reliable data for predicting the performance of larger Opticap XL and XLT production-scale capsules. The OptiScale 47 format allows researchers to evaluate filtration throughput and clogging characteristics using minimal sample volumes, ensuring a cost-effective path to full-scale process validation. Constructed with a high-purity polypropylene housing and featuring standardized hose barb connections, the SN50A47HH3 offers broad chemical compatibility and an exceptionally low extractable profile for sensitive biopharmaceutical and industrial applications.

Technical Performance and Design

• Process Scale-Up Accuracy: Utilizes the exact same Polygard-CN media found in full-sized production filters, ensuring that laboratory-scale flow and retention data translate directly to larger manufacturing volumes.

• Polygard-CN Depth Media: The 5 µm nominal pore size features a graduated-density structure that effectively removes a wide range of particulates, protecting downstream sterilizing-grade membranes from premature fouling.

• Small-Volume Efficiency: The 47 mm disc format (approx. 17.3 cm² filtration area) is optimized for benchtop trials where sample availability is limited or high-value biologicals are being processed.

• Robust Capsule Design: The disposable, lightweight housing eliminates the need for stainless steel filter holders and the associated labor of cleaning and assembly, reducing the risk of cross-contamination.

Product Specifications

• Catalog Number: SN50A47HH3

• Media Type: Polygard-CN (Polypropylene Depth Media)

• Pore Size: 5.0 µm (Nominal)

• Filtration Diameter: 47 mm

• Filtration Area: 17.3 cm²

• Inlet/Outlet Connections: 1/4 inch (6.4 mm) Hose Barb

• Maximum Operating Pressure: 45 psi (3.1 bar) at 25°C.

• Materials: Polypropylene Housing and Support; Silicone O-rings.

Key Benefits & Applications

• Filterability (Vmax) Testing: The primary tool for determining the "maximum filtered volume" of a specific fluid stream before filter plugging occurs.

• Bioprocess Development: Used to select the optimal pre-filtration pore size for cell culture harvests, buffers, and protein-rich intermediates.

• Small-Batch Clarification: Ideal for the rapid clarification of small research batches (100 ml to 2 Liters) where a full-sized capsule is not required.

• Downstream Protection: Effectively removes lipids, aggregates, and large particulates to extend the life of expensive 0.22 µm final filters.

All product names, logos, and brands are property of their respective owners.