Millipore Filter Capsule Opticap XL 10 Polygard-CN 5 um

Millipore KN50A10TT1 Opticap XL 10 Polygard-CN 5 µm Filter Capsule

The Millipore KN50A10TT1 is a high-performance, disposable Opticap XL 10 capsule filter designed for the efficient clarification and pre-filtration of process fluids in biopharmaceutical and industrial applications. Featuring 5 µm Polygard-CN depth media, this capsule utilizes a graduated-density polypropylene fleece structure to provide superior dirt-holding capacity and exceptionally high flow rates. The Opticap XL 10 design is engineered for seamless process scale-up, offering a large filtration surface area that reduces the frequency of filter changes during large-volume processing. With a robust all-polypropylene construction and 1.5-inch sanitary flange connections, the KN50A10TT1 provides a secure, leak-proof solution for protecting sensitive downstream membranes and ensuring the purity of biological intermediates.

Technical Performance and Design

• Polygard-CN Graduated Media: The 5 µm nominal pore size media features multiple layers of depth-filtration material that trap a broad spectrum of particulate sizes, effectively extending the life of downstream sterilizing-grade filters.

• High Throughput XL 10 Format: With a filtration area of 0.38 m² (4.1 ft²), this 10-inch nominal capsule is optimized for handling larger fluid volumes with minimal pressure drop and maximum particulate retention.

• Chemically Inert Materials: Both the media and housing are manufactured from high-purity polypropylene, ensuring broad compatibility with acids, bases, and solvents while maintaining ultra-low extractable levels.

• Sanitary Tri-Clamp Interface: Equipped with 1.5-inch (38 mm) sanitary flange connections on both the inlet and outlet, ensuring aseptic integrity and compatibility with standard stainless steel and single-use bioprocessing hardware.

Product Specifications

• Catalog Number: KN50A10TT1

• Device Size: Opticap XL 10 (10-inch nominal length)

• Pore Size: 5.0 µm (Nominal)

• Filtration Area: 0.38 m² (4.1 ft²)

• Inlet/Outlet Connections: 1.5 in. (38 mm) Sanitary Flange (Tri-Clamp)

• Maximum Operating Pressure: 80 psi (5.5 bar) at 25°C

• Materials of Construction: Polypropylene (Media/Housing); Silicone (O-rings)

• Sterilization: Autoclavable (up to 3 cycles at 126°C); not designed for in-line steam sterilization.

Key Benefits & Applications

• Pre-Filtration & Clarification: Ideally suited for the removal of cell debris, lipids, and large aggregates from cell culture harvests and biological buffers.

• Sterilizing Filter Protection: Significantly increases the total throughput of expensive 0.22 µm final filters by removing the bulk of the particulate load upstream.

• Biopharma Pilot Production: The XL 10 format is the preferred scale for researchers moving from benchtop trials to pilot-scale manufacturing batches.

• Low Protein Binding: The pure polypropylene matrix ensures high recovery rates for proteins, vaccines, and other high-value active pharmaceutical ingredients (APIs).

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