Millipore Filter Capsule Polysep II Opticap XL 4 MCE 0.2 um 10 Filters

Millipore KGW3A04TT3 Polysep™ II Opticap® XL 4 Capsule (1.0/0.2 µm, MCE/Glass Fiber)

The Millipore KGW3A04TT3 is a high-capacity, disposable capsule filter designed for the challenging prefiltration and clarification of aqueous-based solutions. Featuring the proprietary Polysep™ II media, this capsule utilizes a double-layer format: a depth-loading borosilicate glass fiber prefilter and a high-retention mixed cellulose esters (MCE) membrane. This combination allows for the effective removal of lipids, colloids, and heavy particulates while maintaining superior flow rates and protecting expensive downstream sterilizing filters. The Opticap® XL 4 design features a patented housing that withstands high thermal and hydraulic stress, making it a reliable choice for pharmaceutical and biotechnological production environments.

Technical Performance and Design

• Polysep™ II Double-Layer Media: The 1.0 µm glass fiber layer provides massive dirt-holding capacity for large aggregates, while the 0.2 µm MCE layer ensures consistent bioburden reduction and fine particle retention.

• Optimized for Aqueous Solutions: Naturally hydrophilic media requires no pre-wetting agents and offers excellent thermal stability, making it ideal for buffer prep, cell culture media, and ophthalmics.

• Sanitary Flange Connections (TT3): Equipped with 1-1/2 inch (38 mm) Sanitary Flanges on both the inlet and outlet, providing a secure, aseptic interface compatible with standard Tri-Clamp fittings.

• High Surface Area: The XL 4 format provides 0.11 m² of filtration area, offering a compact footprint for mid-scale processing batches (typically 10 to 100 Liters).

Product Specifications

• Catalog Number: KGW3A04TT3

• Media Type: Polysep™ II (BGF prefilter / MCE membrane)

• Pore Size: 1.0/0.2 µm (Nominal)

• Filtration Area: 0.11 m² (1.2 ft²)

• Connections (Inlet/Outlet): 1-1/2 inch Sanitary Flange (TC)

• Dimensions: 19.6 cm (7.7 in.) Length; 8.4 cm (3.3 in.) Diameter

• Max Operating Pressure: 5.5 bar (80 psi) @ 25 °C; 1.0 bar (15 psi) @ 80 °C

• Sterility/Sanitation: Non-sterile; Autoclavable (up to 3 cycles of 30 min @ 121 °C).

Key Benefits & Applications

• Serum & Media Clarification: Effectively removes lipids and colloidal contaminants from serum-supplemented media without obstructing the passage of vital proteins or growth factors.

• LVP Prefiltration: Extends the life of final sterilizing filters in Large Volume Parenteral (LVP) manufacturing by removing the bulk particulate load early in the process.

• Disposable Efficiency: The self-contained capsule design eliminates the labor and expense of cleaning and validating stainless steel housings, reducing the risk of cross-contamination.

• Regulatory Compliance: Meets FDA Indirect Food Additive requirements (21 CFR 177-182) and is certified non-fiber releasing per 21 CFR 210.3(b)(6).

All product names, logos, and brands are property of their respective owners. Opticap and Polysep are registered trademarks of Merck KGaA or its affiliates.