Millipore Filter Microplate 96 Well 0.45 um Deep Well Solvinert 8 Filter Plates

Millipore MultiScreen Solvinert Filter Plate – 96-Well, Deep Well, 0.45 µm, Hydrophobic PTFE

The Millipore MDRLN0410 MultiScreen Solvinert is a high-performance 96-well deep-well filter plate engineered for superior chemical resistance and maximum sample recovery. Featuring a 0.45 µm hydrophobic PTFE (polytetrafluoroethylene) membrane, this plate is specifically designed for applications involving aggressive organic solvents and aqueous/organic mixtures where standard filter plates would fail. The deep-well format provides a high volume capacity, allowing for extended incubation times and larger sample processing. Built with a chemically inert housing, the MDRLN0410 ensures low extractables and high filtration efficiency, making it an essential tool for drug discovery, clinical proteomics, and environmental analysis.

Technical Performance and Design

• Total Solvent Resistance: The hydrophobic PTFE membrane and specialized plate materials are compatible with a wide range of harsh chemicals, including acetonitrile, DMSO, and tetrahydrofuran (THF).

• 0.45 µm Pore Size: Provides effective clarification and particulate removal, ensuring clean filtrates for subsequent analytical steps such as HPLC or LC-MS/MS.

• Deep-Well Capacity: Designed for high-volume filtration, accommodating larger starting samples or facilitating in-well reactions and extended extraction protocols.

• Proprietary Sealing Technology: Engineered to prevent crosstalk between wells and ensure that the vacuum or centrifugal force is applied uniformly across the entire 96-well array.

Product Specifications

• Catalog Number: MDRLN0410

• Format: 96-Well Deep Well

• Membrane Material: Hydrophobic PTFE

• Pore Size: 0.45 µm

• Plate Material: Chemically resistant Polypropylene

• Automation Compatibility: Follows standard ANSI/SLAS dimensions for integration with robotic workstations and vacuum manifolds.

• Packaging: Typically sold in packs of 10 plates.

Key Benefits & Applications

• Protein Precipitation: Optimized for removing precipitated proteins from serum or plasma samples following the addition of organic solvents during drug metabolism studies.

• Combinatorial Chemistry: Provides a robust platform for solid-phase synthesis and subsequent cleavage of compounds using aggressive acidic or basic reagents.

• HPLC/MS Sample Prep: Reduces baseline noise and protects expensive analytical columns by ensuring that filtrates are free of micro-particulates and extractable contaminants.

• Low Non-Specific Binding: The PTFE membrane minimizes the adsorption of target analytes, ensuring high recovery of precious pharmaceutical or biological compounds.

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