Millipore Millistak+ Pod Depth Filter 23 cm2 Single Filter

Millipore MCE5023CL3 Millistak+ $\mu$Pod Depth Filter (CE50 Media, 23 cm²)

The Millipore MCE5023CL3 is a specialized $\mu$Pod® depth filter designed for small-scale process development, media screening, and laboratory-scale clarification. This device features the CE50 filter grade, a high-performance cellulose-based media series that provides a gradient density matrix optimized for primary clarification of cell cultures and fermentation lysates. The $\mu$Pod format offers an effective filtration area of 23 cm², allowing researchers to accurately predict the performance of larger Millistak+ Pod systems while minimizing the consumption of expensive biological feedstreams. Encapsulated in a robust, glass-filled polypropylene housing, this filter ensures a secure, closed system that protects both the operator and the sample from contamination.

Technical Performance and Design

• CE50 Primary Clarification Media: Comprised of high-purity cellulose, the CE50 grade is engineered for coarse clarification, effectively removing cells, large cellular debris, and whole microorganisms from serum, plasma, and vaccine harvests.

• Scalable $\mu$Pod Architecture: The 23 cm² surface area is strategically designed to provide linear scalability to pilot and production-scale Pod systems, ensuring that bench-top results translate accurately to manufacturing volumes.

• Low Hold-up Volume: The compact internal design of the $\mu$Pod minimizes dead space, ensuring high product recovery and reducing the waste of high-value biological products during the clarification step.

• Luer Fitting Connections: Features standardized Luer-lok compatible ports for quick and easy integration into laboratory tubing sets, syringes, or automated small-scale peristaltic pump systems.

Product Specifications

• Catalog Number: MCE5023CL3

• Filtration Area: 23 cm² (0.0023 m²)

• Media Type: CE50 (Cellulose-based)

• Device Configuration: $\mu$Pod® (Process Development Scale)

• Housing Material: Glass-filled Polypropylene

• Max Differential Pressure: Forward: 2.1 bar (30 psid) @ 40°C; Reverse: 1.0 bar (15 psid) @ 40°C

• Sterility: Non-Sterile (Autoclavable: 2 cycles of 60 min at 123°C)

• Dimensions: 6.6 cm (H) x 8.9 cm (L)

Key Benefits & Applications

• Biopharmaceutical Clarification: The preferred tool for harvesting monoclonal antibodies (mAbs), recombinant proteins, and viral vectors from cell culture supernatants.

• Media & Buffer Prep: Excellent for the pre-filtration of growth media or complex buffers containing components that may prematurely plug 0.22 µm sterile filters.

• Disposable & Safe: The self-contained, single-use design eliminates the need for housing cleaning, CIP (Clean-in-Place) protocols, or cleaning validation, significantly reducing turnaround time.

• Low Endotoxin Levels: Certified to contain <0.25 EU/mL (LAL test), ensuring the filter does not introduce pyrogenic contaminants into sensitive biological processes.

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