Millipore MultiScreen Filter Plate 96 Well 0.45um PVDF Pack of 10 Filter Plates

Millipore S5EJ044I10 MultiScreen® Solvinert™ Filter Plate (0.45 µm PVDF)

The Millipore S5EJ044I10 is a high-performance 96-well filter plate specifically engineered for applications involving aggressive organic solvents and complex chemical matrices. Part of the Solvinert™ series, this plate features a specialized 0.45 µm PVDF (Polyvinylidene Fluoride) membrane integrated into a chemically resistant housing. Unlike standard plates, the Solvinert™ design is optimized for high recovery of small molecules and exceptionally low extractables, ensuring the purity of downstream analytical results. Designed to meet ANSI/SLAS standards, this plate is fully compatible with robotic workstations and vacuum manifolds, making it the preferred choice for pharmaceutical laboratories performing sample preparation, drug metabolism (DMPK) studies, and total drug analysis.

Technical Performance and Design

• Solvent-Resistant Construction: Both the membrane and the plate housing are manufactured from materials that resist degradation when exposed to common HPLC solvents, including acetonitrile, methanol, and DMSO.

• Ultra-Low Extractables: Engineered to minimize the release of background contaminants, ensuring that LC-MS/MS and HPLC peaks are clean and accurate for high-sensitivity quantitation.

• High Recovery Membrane: The 0.45 µm PVDF media provides excellent flow rates while maintaining low non-specific binding, ensuring that precious samples and target analytes are not lost on the filter matrix.

• Optimized Fluidics: Features a rigid underdrain design that directs filtrate into collection plates without well-to-well crosstalk or aerosol formation.

Product Specifications

• Catalog Number: S5EJ044I10

• Membrane Type: 0.45 µm PVDF (Hydrophilic)

• Plate Material: Solvent-Resistant Polymer

• Well Volume: 300 µL

• Format: 96-Well MultiScreen® Solvinert™

• Automation Compatibility: Standard ANSI/SLAS Footprint

• Packaging: Pack of 10 plates.

Key Benefits & Applications

• Sample Prep for LC-MS/MS: Ideal for protein precipitation and sample filtration prior to sensitive mass spectrometry analysis.

• Drug Discovery & DMPK: Used extensively for metabolic stability assays and pharmacokinetic studies where organic solvent usage is high.

• Solid Phase Extraction (SPE): Provides a robust platform for small-scale cleanup and concentration of samples in chemical synthesis workflows.

• Total Drug Analysis: Preferred for assays where high chemical resistance is required to maintain the integrity of the well structure throughout long incubation periods.

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