Millipore Pod Depth Filter Clarisolve 20 um 23 cm2 - Case of 3 Filters

Millipore CS20MS01L3 Clarisolve uPod Depth Filter – 20MS Media, 23 cm2

The Millipore CS20MS01L3 is a high-capacity primary clarification filter designed for bench-scale process development and small-volume clarification workflows. Featuring Clarisolve 20MS gradient-density media, this filter is specifically optimized to process high-density cell cultures that have undergone flocculation or chemical pre-treatment. The 20MS media provides an open, coarse structure that captures large cellular aggregates while maintaining high flow rates, effectively replacing centrifugation in many upstream bioprocessing applications. Encapsulated in a robust polypropylene uPod housing, this device ensures linear scalability to larger Clarisolve Pod systems, providing a reliable model for pilot and production-scale manufacturing.

Technical Performance and Design

• Clarisolve 20MS Media: Specifically designed with a 20 micron nominal rating and a gradient density matrix to handle the high solids and large particle sizes found in pre-treated biological feedstreams.

• Linear Scalability: The uPod architecture is strategically engineered to provide predictable performance data that translates directly to lab-scale, pilot-scale, and process-scale Clarisolve Pod assemblies.

• Aseptic Integrity: The fully encapsulated design maintains a closed flow path, reducing the risk of biohazardous aerosols and protecting the sample from environmental contaminants.

• Ready for Integration: Equipped with standardized Luer-lok compatible ports for fast, tool-free connection to syringes, laboratory tubing, or small-scale peristaltic pumps.

Product Specifications

• Catalog Number: CS20MS01L3

• Filter Media: Clarisolve 20MS (Gradient Density)

• Filtration Area: 23 cm2 (0.0023 m2)

• Device Format: uPod (Process Development Scale)

• Housing Material: Glass-filled Polypropylene

• Max Pressure: Forward: 2.1 bar (30 psid) @ 40°C; Reverse: 1.0 bar (15 psid) @ 40°C

Key Benefits & Applications

• Flocculated Feed Processing: The industry-leading choice for clarifying mammalian cell cultures (CHO) that have been pre-treated to increase particle size for faster settling and filtration.

• Centrifugation Replacement: Enables a fully disposable, single-stage clarification process, eliminating the capital expense and cleaning validation associated with traditional laboratory centrifuges.

• High Volumetric Capacity: Optimized to provide superior throughput per unit area compared to traditional depth filters when processing challenging, high-turbidity harvests.

• Purity Standards: Certified to contain <0.25 EU/mL (LAL test), ensuring the filter maintains the high quality required for biopharmaceutical R&D.

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