Millipore Amicon Ultra-4 Centrifugal Filter 10K 4 ml Pack of 24 Filters

Millipore Amicon Ultra-4 Centrifugal Filter Unit, 10 kDa MWCO, 4 mL Volume (UCF801024) – Pack of 24 Units

The Millipore Amicon Ultra-4 Centrifugal Filter (UCF801024) is a high-performance sample preparation device engineered for the rapid concentration, desalinating, buffer exchange, and diafiltration of biological samples such as proteins, antibodies, nucleic acids, and viral vectors. Featuring a 10 kDa Molecular Weight Cut-Off (MWCO) regenerated cellulose Ultracel membrane, this filter unit provides high solute recovery (typically greater than 90%) while minimizing non-specific binding. Its unique vertical membrane design reduces solute polarization and fouling, allowing rapid spin times—often under 15 minutes—even with viscous solutions. The unit accommodates sample volumes up to 4 mL in swinging-bucket or fixed-angle rotors and features a dead-stop pocket that prevents spinning to dryness, protecting sensitive biomolecules from over-concentration. Supplied as a pack of 24 complete filter units with collection tubes, the UCF801024 is an essential tool for downstream analytical, structural, and bioprocess laboratory workflows.

Technical Performance & Structural Attributes

• Ultracel Regenerated Cellulose Membrane: Low-binding, high-purity membrane delivers high recovery rates for proteins and macromolecules above 10 kDa.
• Vertical Membrane Geometry: Parallel flow orientation reduces concentration polarization and membrane fouling, maintaining high filtration speeds.
• Integrated Dead-Stop Design: Built-in concentrate pocket prevents sample drying, ensuring consistent concentration factors (up to 28-fold to 80-fold) without user monitoring.
• Rotor Compatibility: Designed for use in standard 15 mL centrifuge rotors, accommodating both swinging-bucket and 25-degree fixed-angle configurations.
• Transparent Graduated Housing: Clear polypropylene housing with printed volume graduations enables quick visual inspection of sample retentate volumes.

Product Specifications

• Catalog / Part Number: UCF801024
• Primary Manufacturer: EMD Millipore (MilliporeSigma / Merck KGaA)
• Equipment Category: Laboratory Centrifugal Ultrafiltration Devices
• Membrane Type: Ultracel Low-Binding Regenerated Cellulose
• Nominal Molecular Weight Limit (NMWL) / MWCO: 10 kDa (10,000 Da)
• Maximum Initial Sample Volume: 4.0 mL
• Final Concentrate Volume: 30 µL to 70 µL (Dead-stop volume range)
• Maximum Centrifugal Force: 4,000 x g (Swinging-bucket rotor) / 7,500 x g (Fixed-angle 25-degree rotor)
• Filter Housing & Tube Material: Polypropylene Housing with Polyethylene Cap and Liner
• Active Membrane Area: 3.0 cm squared
• Dimensions (Diameter x Length): 17 mm x 124 mm
• Packaging Configuration: Pack of 24 Complete Filter Units with Collection Tubes

Key Benefits & Applications

• Protein & Antibody Concentration: Rapidly concentrates diluted proteins, enzymes, and monoclonal antibodies prior to structural or functional assays.
• Desalting & Buffer Exchange: Efficiently removes salts, unincorporated radiolabels, inhibitors, and small molecules via diafiltration.
• HPLC & Mass Spectrometry Sample Clean Up: Clarifies biological matrices and removes high-molecular-weight interferences to protect analytical columns and detectors.

All product names, logos, and brands are property of their respective owners. Millipore, Amicon, and Ultracel are registered trademarks of Merck KGaA, Darmstadt, Germany or its affiliates.