Natrix NatriFlo Mini Membrane Filter HD-Q Recon Box of 10 Filters

Natrix NXF-01 NatriFlo HD-Q Mini (Recon) – High Productivity Q-Chromatography

The Natrix NXF-01 is a laboratory-scale membrane chromatography module designed for rapid process development and impurity clearance screening. Utilizing Natrix HD-Q technology, this module features a high-density quaternary amine (strong anion exchange) functionalized hydrogel within a macroporous membrane matrix. This "Recon" scale device provides a nominal 1 mL membrane volume, making it the ideal tool for evaluating binding capacity and flow-through efficiency while using minimal sample volumes. The NXF-01 is specifically engineered for "negative mode" chromatography, offering exceptional removal of DNA, host cell proteins (HCP), and viral contaminants in a single pass with significantly higher productivity than traditional resin-based columns.

Technical Performance and Design

• HD-Q Hydrogel Technology: High-density Quaternary Amine chemistry provides superior binding capacity for negatively charged impurities, maintaining high performance even at high conductivity and elevated flow rates.

• Macroporous Membrane Architecture: The unique structure allows for convective flow and rapid mass transfer, eliminating the diffusion limitations common in bead-based resins and allowing for faster processing times.

• 1 mL Recon Scale: Optimized for benchtop screening and method development, providing a cost-effective way to determine optimal loading conditions and buffer requirements.

• Standard Luer Connections: Equipped with female luer lock inlet and male luer outlet ports for easy integration with laboratory syringes, manifolds, or AKTA chromatography systems.

Product Specifications

• Catalog Number: NXF-01

• Chemistry: HD-Q (Strong Anion Exchange / Quaternary Amine)

• Device Format: NatriFlo Mini (Recon Scale)

• Nominal Membrane Volume: 1 mL

• Flow Mode: Negative Mode / Flow-Through Chromatography

• Housing Material: Polypropylene

Key Benefits & Applications

• Impurity Clearance Screening: The preferred tool for initial studies on the removal of genomic DNA, host cell proteins (HCP), and endotoxins from recombinant protein harvests.

• Viral Clearance Validation: Frequently used in small-scale viral spiking studies to determine Log Reduction Values (LRV) for biopharmaceutical safety protocols.

• Method Optimization: Allows for the rapid testing of various pH and conductivity conditions to maximize throughput before scaling up to NXF-10 or production-scale modules.

• Single-Use Convenience: The disposable format eliminates the need for column packing, cleaning validation, and cross-contamination risks, streamlining lab workflows.

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