Novasep Filter Cassette SIUS Prostream Low Binding PES 0.01 m2 300 kD

Novasep (Repligen) SIUS PD PP300LP1L Filter Cassette – ProStream PES, 300 kD, 0.01 m²

The PP300LP1L is a specialized Tangential Flow Filtration (TFF) cassette belonging to the SIUS PD (Process Development) line, originally developed by Novasep/TangenX and now part of the Repligen portfolio. This purpose-built, single-use module is equipped with a ProStream Polyethersulfone (PES) membrane featuring a high-clearance 300 kD Molecular Weight Cut-Off (MWCO). With a compact 0.01 m² effective filtration area, it is the ideal tool for small-volume R&D, pilot studies, and process optimization. Designed to completely bypass the need for cleaning validation and sterilization, this ready-to-use cassette accelerates downstream bioprocessing while providing incredibly reliable linear scale-up data for larger manufacturing runs.

Technical Performance and Design

• ProStream PES Membrane: The highly hydrophilic Polyethersulfone chemistry ensures ultra-low non-specific protein binding. This maximizes product recovery and sustains high flux rates by preventing the membrane surface from prematurely fouling.

• 300 kD MWCO: This large pore size is precisely engineered to retain massive biological structures—such as viral vectors, virus-like particles (VLPs), plasmids, and extracellular vesicles—while allowing smaller host cell proteins and buffers to pass freely into the permeate.

• "L" Screen Channel Geometry: The L-screen format provides a medium channel height that perfectly balances sheer rate and pressure drop, making it highly effective for handling fluids with moderate viscosities without clogging.

• True Single-Use (SIUS) Architecture: Arrives ready to process. By eliminating the massive water and labor requirements of Clean-in-Place (CIP) protocols, it drastically reduces batch turnaround times and completely neutralizes the risk of cross-contamination.

Product Specifications

• Catalog Number: PP300LP1L

• Product Line: SIUS PD (Process Development)

• Membrane Material: ProStream Polyethersulfone (PES)

• Molecular Weight Cut-Off (MWCO): 300 kD

• Effective Filtration Area: 0.01 m²

• Channel Type: L Screen (Medium)

• Format: Single-Use TFF Cassette

Key Benefits & Applications

• Gene Therapy & Virology: The 300 kD rating is an industry standard for the concentration and diafiltration of Lentiviruses and Adeno-Associated Viruses (AAV) during downstream purification.

• Economical R&D: The 0.01 m² size is perfect for benchtop feasibility studies, allowing process engineers to test separation parameters on rare, high-value samples before committing to large-scale filter blocks.

• Predictable Scale-Up: The fluid path length and channel geometry are identical to massive commercial-scale SIUS cassettes, ensuring that your R&D flow rates and transmembrane pressures (TMP) scale perfectly to production.

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Expiration: 20-Jan-2018.