Novasep Sius Filter Isolation Plate Pack of 3 Sealed Plates

Novasep Sius LS LHV Filter Isolation Plate – Low Hold-up Volume, TFPLS-LVFL

The Novasep TFPLS-LVFL is a precision-engineered Filter Isolation Plate designed for use within the Sius LS Tangential Flow Filtration (TFF) hardware platform. Engineered with a specialized Low Hold-up Volume (LHV) architecture, this plate is utilized to isolate or "blank off" specific filter cassettes within a multi-cassette stack. This allows process engineers to maintain the structural integrity of the TFF holder while selectively reducing the active filtration area to match specific batch requirements. By minimizing internal fluid pathways, the LHV design ensures maximum product recovery and reduces the dilution of high-value biologicals during the elution and recovery phases of downstream processing.

Technical Performance and Design

• Low Hold-up Volume (LHV) Optimization: The internal flow channels are designed with a minimalist geometry to significantly reduce the "dead volume" of fluid trapped within the plate. This is critical for high-concentration factors where every milliliter of product recovery directly impacts the final batch yield.

• Universal Sius LS Compatibility: Specifically dimensioned to fit seamlessly into the Sius LS plate-and-frame holders. Its surface finish and port alignments are precision-matched to industry-standard TFF cassettes, ensuring a leak-proof seal under high-pressure transmembrane conditions.

• Chemical & Thermal Resistance: Manufactured from high-grade, biopharmaceutical-compatible polymers (typically 316L stainless steel or high-performance engineered plastics depending on the specific sub-configuration), it is fully resistant to common CIP (Clean-in-Place) chemicals such as 1N NaOH and sodium hypochlorite.

• Standardized Porting: Features exact port alignments that maintain the laminar flow characteristics of the TFF stack, preventing turbulent zones that could lead to protein denaturation or increased shear stress on sensitive cells.

Product Specifications

• Catalog Number: TFPLS-LVFL

• Product Line: Sius LS TFF System

• Component Type: Filter Isolation Plate (Blanking Plate)

• Design Profile: Low Hold-up Volume (LHV)

• Application: Cassette Isolation, Area Scaling, and Dead-Volume Reduction

• Biocompatibility: USP Class VI compliant materials

Key Benefits & Applications

• Process Scaling Flexibility: Allows a single Sius LS holder to be used for varying batch sizes. By using the TFPLS-LVFL to isolate unused slots, a large-scale holder can be "scaled down" for pilot studies without requiring a completely different hardware set.

• High-Concentration Recovery: Ideal for final formulation steps where the target protein concentration is high; the LHV design ensures that the protein remains in the retentate stream rather than being lost in the manifold dead-legs.

• Integrity Test Support: Enables the isolation of individual cassettes during troubleshooting or multi-filter integrity testing, allowing technicians to identify a single failing unit without dismantling the entire stack.

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