Pall Allegro Recirculation Starter Kit 10 L 2 Starter Kits

Pall Allegro 6415-0537T Recirculation Starter Kit – 10 L, Single-Use, Sterile

The Pall Allegro 6415-0537T Recirculation Starter Kit is a comprehensive, single-use solution designed to rapidly establish and optimize 10-Liter tangential flow filtration (TFF) loops. Engineered to seamlessly enhance the performance of Allegro crossflow systems, this pre-assembled kit provides all the essential fluid path components necessary to enable continuous, high-efficiency fluid recirculation. By sustaining consistent crossflow velocities and minimizing dead legs, it actively maximizes filter capacity, prevents premature membrane fouling, and ensures superior product recovery during the processing of delicate biologicals. Supplied pre-sterilized and ready to deploy, this kit eliminates the need for complex custom plumbing and completely bypasses rigorous cleaning validation procedures.

Technical Performance and Design

• Pre-Assembled Closed System: Comes pre-plumbed with high-purity, biopharmaceutical-grade tubing and secure, leak-proof connections. This dramatically reduces setup time and virtually eliminates the risk of operator-induced assembly errors or environmental contamination.

• Optimized Fluid Dynamics: Specifically engineered to maintain the steady crossflow rates and optimal pressures required for advanced ultrafiltration and microfiltration, ensuring high permeate flux without inducing shear damage to target proteins.

• 10-Liter Capacity: The perfect intermediate volume for benchtop pilot studies, process optimization, and the production of early-phase clinical materials prior to full commercial scale-up.

• Absolute Single-Use Efficiency: The fully disposable architecture removes the massive pure water and labor requirements associated with traditional stainless steel Clean-in-Place (CIP) and Sterilize-in-Place (SIP) protocols.

Product Specifications

• Catalog Number: 6415-0537T

• Product Line: Allegro Single-Use Systems

• Format: Recirculation Starter Kit (TFF / Crossflow)

• Working Volume: 10 Liters

• System Compatibility: Allegro and Cadence Filtration Systems

• Sterility: Single-Use, Pre-sterilized

Key Benefits & Applications

• Downstream Bioprocessing: The industry-standard configuration for the rapid concentration and automated buffer exchange (diafiltration) of monoclonal antibodies (mAbs), viral vectors, and recombinant proteins.

• Process Standardization: Utilizing an off-the-shelf starter kit guarantees that every R&D and pilot run operates with the exact same fluid dynamics and contact materials, vastly improving lot-to-lot reproducibility.

• Maximized Uptime: Enables technicians to transition from one batch to the next in a matter of minutes simply by swapping out the single-use kit, keeping expensive TFF pumping hardware in continuous operation.

• Reliable Scalability: Because the materials and flow paths mirror larger Pall commercial-scale TFF skids, engineers can generate highly reliable data for linear scale-up calculations.

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