Phenomenex Strata-X-CW Microplate 30 mg Weak Cation 96 Well 2 Sealed Plates

Phenomenex Strata-X-CW SPE Microplate – 30 mg/well, Weak Cation, 96-Well

The Phenomenex 8E-S035-TGB is a high-performance Solid Phase Extraction (SPE) microplate engineered for the rapid, high-throughput isolation of strongly basic compounds. Each well in the 96-well polypropylene manifold contains 30 mg of Strata-X-CW, a 33 µm polymeric weak cation-exchange sorbent. Unlike traditional silica-based sorbents, this rugged polymeric backbone resists deconditioning if accidentally dried out during the conditioning or washing steps, entirely eliminating the risk of lost sample recoveries. The uniquely modified mixed-mode chemistry uniformly bonds a carboxylic acid ligand to the polymer, offering three mechanisms of retention (weak cation exchange, pi-pi bonding, and hydrophobic interactions). This strong ionic binding allows researchers to aggressively wash away matrix interferences using 100% organic solvents, resulting in ultra-clean extracts that significantly improve LC-MS/MS sensitivity.

Technical Performance and Design

• Mixed-Mode Retention: Synergistically combines weak cation-exchange capabilities with reversed-phase (hydrophobic and pi-pi) bonding, providing unparalleled selectivity and retention for strongly basic analytes (pKa > 8).

• 100% Organic Wash Capability: The strong ionic binding of target bases enables the use of 100% organic solvents during the wash step, effectively stripping away neutral interferences, phospholipids, and particulates without analyte breakthrough.

• Resistant to Drying: The advanced polymeric backbone prevents the sorbent from collapsing, ensuring that accidental drying under a vacuum manifold will not compromise sensitive extraction recoveries.

• High-Throughput 96-Well Format: Built into a standard SBS-footprint polypropylene plate, making it seamlessly compatible with automated liquid handling robots, positive pressure manifolds, and 96-well vacuum blocks for rapid batch processing.

Product Specifications

• Catalog Number: 8E-S035-TGB

• Format: 96-Well Plate

• Phase/Chemistry: Strata-X-CW (Polymeric Weak Cation Mixed Mode)

• Particle Size: 33 µm (85 Å Pore Size)

• Sorbent Mass: 30 mg per well

• Housing Material: Polypropylene

• Target Analytes: Strong Bases and Quaternary Amines (pKa > 8)

Key Benefits & Applications

• Clinical & Toxicological Assays: The industry standard for the high-throughput extraction of strongly basic pharmaceutical compounds, drugs of abuse, and metabolites from complex biological fluids like blood plasma, serum, and urine.

• LC-MS/MS Optimization: Highly effective at stripping away phospholipids and salts, preventing the severe ion-suppression effects that frequently plague sensitive mass spectrometry detectors.

• Environmental Testing: Allows for the rapid concentration of trace-level strongly basic contaminants from municipal water and soil extracts.

• Solvent Switching & Concentration: Allows researchers to elute target compounds directly into a minimal volume of mass-spec friendly solvent, bypassing time-consuming evaporation and reconstitution steps.

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