Repligen Bottle Assembly 1 Liter Non-Irradiated Reservoir Vacuum Bottle

Repligen ACBT-1TC KrosFlo Reservoir Assembly – 1 Liter, HB and TC Ports

The Repligen ACBT-1TC is a specialized 1-Liter process vessel engineered specifically for use with benchtop Tangential Flow Filtration (TFF) systems. What makes this reservoir unique is its hybrid port configuration. It utilizes standard Hose Barbs (HB) for low-pressure tasks like venting or buffer addition, while incorporating robust Tri-Clamp (TC) sanitary connections for the main process lines. This ensures a highly secure, leak-free interface with the feed pump and retentate stream, even under the elevated pressures required for efficient cross-flow filtration.

Technical Performance and Design

• Hybrid Port Technology: The combination of TC and HB ports gives process engineers the best of both worlds: the high-pressure security of sanitary flanges for the main fluid loop, and the simplicity of hose barbs for auxiliary lines.

• Optimized for TFF: Designed to seamlessly integrate into automated TFF workflows, ensuring efficient sample recirculation and minimal hold-up volume to maximize the recovery of high-value biologicals.

• High-Purity Construction: Manufactured from medical-grade, rigid polypropylene to provide exceptional chemical compatibility and a smooth, crevice-free interior that prevents product entrapment.

• Process Reliability: The sturdy Tri-Clamp connections prevent the tubing blowouts and leaks that can occur with standard barbed fittings when backpressure builds in the filtration loop.

Product Specifications

• Catalog Number: ACBT-1TC (often listed as ACBT-1TC-01N)

• Capacity: 1000 mL (1 Liter)

• Bottle Material: Polypropylene (PP)

• High-Pressure Ports: Tri-Clamp (TC) / Sanitary Flange

• Auxiliary Ports: Hose Barb (HB)

• System Compatibility: Benchtop TFF Systems (e.g., KrosFlo KR2i, FS Systems)

Key Benefits & Applications

• Protein Concentration & Buffer Exchange: The ideal feed reservoir for continuous diafiltration and concentration of monoclonal antibodies, recombinant proteins, and viral vectors.

• Secure Fluid Handling: Tri-Clamp fittings allow for the use of reinforced tubing and sanitary gaskets, ensuring a much safer working environment when pumping high-titer biological fluids.

• Versatile Addition Lines: The integrated hose barbs make it simple to attach a syringe filter for sterile venting or to plumb in an automated buffer addition pump without breaking the closed system.

• Scalability: Using TC connections at the 1-liter benchtop scale accurately mimics the fluid dynamics and connection styles of large-scale pilot and clinical manufacturing tanks.

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